Reduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure

Abstract Whether catheter ablation for atrial fibrillation (AF) improves survival and affects other outcomes in real-world heart failure (HF) patients is unclear. This study aimed to evaluate whether ablation reduces death, and other outcomes in real-world AF patients with HF. Among 834,735 patients...

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Autores principales:	Pil-Sung Yang, Daehoon Kim, Jung-Hoon Sung, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e51060bec23400b9367b565d299a304
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spelling	oai:doaj.org-article:3e51060bec23400b9367b565d299a3042021-12-02T11:35:53ZReduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure10.1038/s41598-021-84256-z2045-2322https://doaj.org/article/3e51060bec23400b9367b565d299a3042021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84256-zhttps://doaj.org/toc/2045-2322Abstract Whether catheter ablation for atrial fibrillation (AF) improves survival and affects other outcomes in real-world heart failure (HF) patients is unclear. This study aimed to evaluate whether ablation reduces death, and other outcomes in real-world AF patients with HF. Among 834,735 patients with AF from 2006 to 2015 in the Korean National Health Insurance Service database, 3173 HF patients underwent AF ablation. Propensity score weighting was used to correct for differences between the groups. During median 54 months follow-up, the risk of all-cause death in ablated patients was less than half of that in patients with medical therapy (2.8 vs. 6.2 per 100 person-years; hazard ratio [HR] 0.42, 95% confidence interval [CI] 0.27–0.65, p < 0.001). Ablation was related with lower risk of cardiovascular death (HR 0.38, 95% CI 0.32–0.62, p < 0.001), HF admission (HR 0.39, 95% CI 0.33–0.46, p < 0.001) and stroke/systemic embolism (HR 0.44, 95% CI 0.37–0.53, p < 0.001). In subgroup analysis, the risk of all-cause death was reduced in most subgroups except in the elderly (≥ 75 years) and strictly anticoagulated patients. Ablation may be associated with reduced risk of all-cause death and cardiovascular death in real-world AF patients with HF, supporting the role of AF ablation in patients with HF.Pil-Sung YangDaehoon KimJung-Hoon SungEunsun JangHee Tae YuTae-Hoon KimJae-Sun UhmJong-Youn KimHui-Nam PakMoon-Hyoung LeeBoyoung JoungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pil-Sung Yang Daehoon Kim Jung-Hoon Sung Eunsun Jang Hee Tae Yu Tae-Hoon Kim Jae-Sun Uhm Jong-Youn Kim Hui-Nam Pak Moon-Hyoung Lee Boyoung Joung Reduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure
description	Abstract Whether catheter ablation for atrial fibrillation (AF) improves survival and affects other outcomes in real-world heart failure (HF) patients is unclear. This study aimed to evaluate whether ablation reduces death, and other outcomes in real-world AF patients with HF. Among 834,735 patients with AF from 2006 to 2015 in the Korean National Health Insurance Service database, 3173 HF patients underwent AF ablation. Propensity score weighting was used to correct for differences between the groups. During median 54 months follow-up, the risk of all-cause death in ablated patients was less than half of that in patients with medical therapy (2.8 vs. 6.2 per 100 person-years; hazard ratio [HR] 0.42, 95% confidence interval [CI] 0.27–0.65, p < 0.001). Ablation was related with lower risk of cardiovascular death (HR 0.38, 95% CI 0.32–0.62, p < 0.001), HF admission (HR 0.39, 95% CI 0.33–0.46, p < 0.001) and stroke/systemic embolism (HR 0.44, 95% CI 0.37–0.53, p < 0.001). In subgroup analysis, the risk of all-cause death was reduced in most subgroups except in the elderly (≥ 75 years) and strictly anticoagulated patients. Ablation may be associated with reduced risk of all-cause death and cardiovascular death in real-world AF patients with HF, supporting the role of AF ablation in patients with HF.
format	article
author	Pil-Sung Yang Daehoon Kim Jung-Hoon Sung Eunsun Jang Hee Tae Yu Tae-Hoon Kim Jae-Sun Uhm Jong-Youn Kim Hui-Nam Pak Moon-Hyoung Lee Boyoung Joung
author_facet	Pil-Sung Yang Daehoon Kim Jung-Hoon Sung Eunsun Jang Hee Tae Yu Tae-Hoon Kim Jae-Sun Uhm Jong-Youn Kim Hui-Nam Pak Moon-Hyoung Lee Boyoung Joung
author_sort	Pil-Sung Yang
title	Reduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure
title_short	Reduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure
title_full	Reduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure
title_fullStr	Reduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure
title_full_unstemmed	Reduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure
title_sort	reduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e51060bec23400b9367b565d299a304
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Reduction of mortality by catheter ablation in real-world atrial fibrillation patients with heart failure

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