Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila

Abstract Reproductive isolation and speciation are driven by the convergence of environmental and genetic variation. The integration of these variation sources is thought to occur through epigenetic marks including DNA methylation. Proteins containing a methyl-CpG-binding domain (MBD) bind methylate...

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Autores principales:	Tarun Gupta, Hannah R. Morgan, Jonathan C. Andrews, Edmond R. Brewer, Sarah J. Certel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e58119df1b54bae8ca6b6a23bdb901d
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spelling	oai:doaj.org-article:3e58119df1b54bae8ca6b6a23bdb901d2021-12-02T12:30:51ZMethyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila10.1038/s41598-017-05844-62045-2322https://doaj.org/article/3e58119df1b54bae8ca6b6a23bdb901d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05844-6https://doaj.org/toc/2045-2322Abstract Reproductive isolation and speciation are driven by the convergence of environmental and genetic variation. The integration of these variation sources is thought to occur through epigenetic marks including DNA methylation. Proteins containing a methyl-CpG-binding domain (MBD) bind methylated DNA and interpret epigenetic marks, providing a dynamic yet evolutionarily adapted cellular output. Here, we report the Drosophila MBD-containing proteins, dMBD-R2 and dMBD2/3, contribute to reproductive isolation and survival behavioral strategies. Drosophila melanogaster males with a reduction in dMBD-R2 specifically in octopamine (OA) neurons exhibit courtship toward divergent interspecies D. virilis and D. yakuba females and a decrease in conspecific mating success. Conspecific male-male courtship is increased between dMBD-R2-deficient males while aggression is reduced. These changes in adaptive behavior are separable as males with a hypermethylated OA neuronal genome exhibited a decrease in aggression without altering male-male courtship. These results suggest Drosophila MBD-containing proteins are required within the OA neural circuitry to inhibit interspecies and conspecific male-male courtship and indicate that the genetically hard-wired neural mechanisms enforcing behavioral reproductive isolation include the interpretation of the epigenome.Tarun GuptaHannah R. MorganJonathan C. AndrewsEdmond R. BrewerSarah J. CertelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tarun Gupta Hannah R. Morgan Jonathan C. Andrews Edmond R. Brewer Sarah J. Certel Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila
description	Abstract Reproductive isolation and speciation are driven by the convergence of environmental and genetic variation. The integration of these variation sources is thought to occur through epigenetic marks including DNA methylation. Proteins containing a methyl-CpG-binding domain (MBD) bind methylated DNA and interpret epigenetic marks, providing a dynamic yet evolutionarily adapted cellular output. Here, we report the Drosophila MBD-containing proteins, dMBD-R2 and dMBD2/3, contribute to reproductive isolation and survival behavioral strategies. Drosophila melanogaster males with a reduction in dMBD-R2 specifically in octopamine (OA) neurons exhibit courtship toward divergent interspecies D. virilis and D. yakuba females and a decrease in conspecific mating success. Conspecific male-male courtship is increased between dMBD-R2-deficient males while aggression is reduced. These changes in adaptive behavior are separable as males with a hypermethylated OA neuronal genome exhibited a decrease in aggression without altering male-male courtship. These results suggest Drosophila MBD-containing proteins are required within the OA neural circuitry to inhibit interspecies and conspecific male-male courtship and indicate that the genetically hard-wired neural mechanisms enforcing behavioral reproductive isolation include the interpretation of the epigenome.
format	article
author	Tarun Gupta Hannah R. Morgan Jonathan C. Andrews Edmond R. Brewer Sarah J. Certel
author_facet	Tarun Gupta Hannah R. Morgan Jonathan C. Andrews Edmond R. Brewer Sarah J. Certel
author_sort	Tarun Gupta
title	Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila
title_short	Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila
title_full	Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila
title_fullStr	Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila
title_full_unstemmed	Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila
title_sort	methyl-cpg binding domain proteins inhibit interspecies courtship and promote aggression in drosophila
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3e58119df1b54bae8ca6b6a23bdb901d
work_keys_str_mv	AT tarungupta methylcpgbindingdomainproteinsinhibitinterspeciescourtshipandpromoteaggressionindrosophila AT hannahrmorgan methylcpgbindingdomainproteinsinhibitinterspeciescourtshipandpromoteaggressionindrosophila AT jonathancandrews methylcpgbindingdomainproteinsinhibitinterspeciescourtshipandpromoteaggressionindrosophila AT edmondrbrewer methylcpgbindingdomainproteinsinhibitinterspeciescourtshipandpromoteaggressionindrosophila AT sarahjcertel methylcpgbindingdomainproteinsinhibitinterspeciescourtshipandpromoteaggressionindrosophila
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Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila

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