Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

Pfs48/45 is a promising component for a transmission-blocking malaria vaccine. Here, the authors develop a system to produce full-length Pfs48/45 for immunisation, characterise a panel of monoclonal antibodies and determine the structure of a potent transmission-blocking epitope.

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Autores principales:	Frank Lennartz, Florian Brod, Rebecca Dabbs, Kazutoyo Miura, David Mekhaiel, Arianna Marini, Matthijs M. Jore, Max M. Søgaard, Thomas Jørgensen, Willem A. de Jongh, Robert W. Sauerwein, Carole A. Long, Sumi Biswas, Matthew K. Higgins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e590003190943eebd4a943c9cadaa5a
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spelling	oai:doaj.org-article:3e590003190943eebd4a943c9cadaa5a2021-12-02T17:32:18ZStructural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody10.1038/s41467-018-06340-92041-1723https://doaj.org/article/3e590003190943eebd4a943c9cadaa5a2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06340-9https://doaj.org/toc/2041-1723Pfs48/45 is a promising component for a transmission-blocking malaria vaccine. Here, the authors develop a system to produce full-length Pfs48/45 for immunisation, characterise a panel of monoclonal antibodies and determine the structure of a potent transmission-blocking epitope.Frank LennartzFlorian BrodRebecca DabbsKazutoyo MiuraDavid MekhaielArianna MariniMatthijs M. JoreMax M. SøgaardThomas JørgensenWillem A. de JonghRobert W. SauerweinCarole A. LongSumi BiswasMatthew K. HigginsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Frank Lennartz Florian Brod Rebecca Dabbs Kazutoyo Miura David Mekhaiel Arianna Marini Matthijs M. Jore Max M. Søgaard Thomas Jørgensen Willem A. de Jongh Robert W. Sauerwein Carole A. Long Sumi Biswas Matthew K. Higgins Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody
description	Pfs48/45 is a promising component for a transmission-blocking malaria vaccine. Here, the authors develop a system to produce full-length Pfs48/45 for immunisation, characterise a panel of monoclonal antibodies and determine the structure of a potent transmission-blocking epitope.
format	article
author	Frank Lennartz Florian Brod Rebecca Dabbs Kazutoyo Miura David Mekhaiel Arianna Marini Matthijs M. Jore Max M. Søgaard Thomas Jørgensen Willem A. de Jongh Robert W. Sauerwein Carole A. Long Sumi Biswas Matthew K. Higgins
author_facet	Frank Lennartz Florian Brod Rebecca Dabbs Kazutoyo Miura David Mekhaiel Arianna Marini Matthijs M. Jore Max M. Søgaard Thomas Jørgensen Willem A. de Jongh Robert W. Sauerwein Carole A. Long Sumi Biswas Matthew K. Higgins
author_sort	Frank Lennartz
title	Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody
title_short	Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody
title_full	Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody
title_fullStr	Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody
title_full_unstemmed	Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody
title_sort	structural basis for recognition of the malaria vaccine candidate pfs48/45 by a transmission blocking antibody
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3e590003190943eebd4a943c9cadaa5a
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Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

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