Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function

Abstract The association of parathyroid hormone (PTH) and vitamin D with Metabolic syndrome (MetS) was evaluated using representative data from the Korean population. Data from 7004 subjects aged 50 or older with preserved renal function (excluding chronic kidney disease stage 3b to 5) who were incl...

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Autores principales:	Min-Hee Kim, Jeongmin Lee, Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Bong Yun Cha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e5d6a9580f34cb4b982411968825747
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spelling	oai:doaj.org-article:3e5d6a9580f34cb4b9824119688257472021-12-02T15:08:36ZGender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function10.1038/s41598-017-17397-92045-2322https://doaj.org/article/3e5d6a9580f34cb4b9824119688257472018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-17397-9https://doaj.org/toc/2045-2322Abstract The association of parathyroid hormone (PTH) and vitamin D with Metabolic syndrome (MetS) was evaluated using representative data from the Korean population. Data from 7004 subjects aged 50 or older with preserved renal function (excluding chronic kidney disease stage 3b to 5) who were included in the Korean National Health and Nutrition Examination Survey between 2008 and 2010 were analysed. Higher PTH levels (pg/ml) were observed in subjects with MetS than in those without MetS among both genders (60.1 (58.6–61.6) vs. 62.4 (60.7–64.2) in males p = 0.018, 60.7 (59.4–62.1) vs. 63.9 (62.4–65.6) in females, p < 0.001). For females, PTH levels were significantly higher in subjects with MetS than in those without MetS after adjustment for possible covariates. Lower 25(OH)D levels were significantly associated with MetS only in male subjects (p = 0.004). As the number of MetS components increased, a significant rise in PTH levels (p for trend 0.005 in males and 0.024 in females) and a decrease in 25(OH)D levels (p for trend < 0.001 in males and 0.053 in females) were observed. In conclusion, among subjects with preserved renal function, PTH levels were possibly associated with MetS in females, whereas vitamin D levels exhibited a possible link to MetS in males.Min-Hee KimJeongmin LeeJeonghoon HaKwanhoon JoDong-Jun LimJung-Min LeeSang-Ah ChangMoo-Il KangBong Yun ChaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min-Hee Kim Jeongmin Lee Jeonghoon Ha Kwanhoon Jo Dong-Jun Lim Jung-Min Lee Sang-Ah Chang Moo-Il Kang Bong Yun Cha Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
description	Abstract The association of parathyroid hormone (PTH) and vitamin D with Metabolic syndrome (MetS) was evaluated using representative data from the Korean population. Data from 7004 subjects aged 50 or older with preserved renal function (excluding chronic kidney disease stage 3b to 5) who were included in the Korean National Health and Nutrition Examination Survey between 2008 and 2010 were analysed. Higher PTH levels (pg/ml) were observed in subjects with MetS than in those without MetS among both genders (60.1 (58.6–61.6) vs. 62.4 (60.7–64.2) in males p = 0.018, 60.7 (59.4–62.1) vs. 63.9 (62.4–65.6) in females, p < 0.001). For females, PTH levels were significantly higher in subjects with MetS than in those without MetS after adjustment for possible covariates. Lower 25(OH)D levels were significantly associated with MetS only in male subjects (p = 0.004). As the number of MetS components increased, a significant rise in PTH levels (p for trend 0.005 in males and 0.024 in females) and a decrease in 25(OH)D levels (p for trend < 0.001 in males and 0.053 in females) were observed. In conclusion, among subjects with preserved renal function, PTH levels were possibly associated with MetS in females, whereas vitamin D levels exhibited a possible link to MetS in males.
format	article
author	Min-Hee Kim Jeongmin Lee Jeonghoon Ha Kwanhoon Jo Dong-Jun Lim Jung-Min Lee Sang-Ah Chang Moo-Il Kang Bong Yun Cha
author_facet	Min-Hee Kim Jeongmin Lee Jeonghoon Ha Kwanhoon Jo Dong-Jun Lim Jung-Min Lee Sang-Ah Chang Moo-Il Kang Bong Yun Cha
author_sort	Min-Hee Kim
title	Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
title_short	Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
title_full	Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
title_fullStr	Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
title_full_unstemmed	Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
title_sort	gender specific association of parathyroid hormone and vitamin d with metabolic syndrome in population with preserved renal function
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3e5d6a9580f34cb4b982411968825747
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Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function

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