Insulated transcriptional elements enable precise design of genetic circuits

Unwanted interactions between cellular components can complicate rational engineering of biological systems. Here the authors design insulated minimal promoters and operators that enable biophysical modeling of bacterial transcription without free parameters for precise circuit design.

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Detalles Bibliográficos
Autores principales:	Yeqing Zong, Haoqian M. Zhang, Cheng Lyu, Xiangyu Ji, Junran Hou, Xian Guo, Qi Ouyang, Chunbo Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e5ebc6575034de280e65ca0e1e373fd
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spelling	oai:doaj.org-article:3e5ebc6575034de280e65ca0e1e373fd2021-12-02T13:27:30ZInsulated transcriptional elements enable precise design of genetic circuits10.1038/s41467-017-00063-z2041-1723https://doaj.org/article/3e5ebc6575034de280e65ca0e1e373fd2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00063-zhttps://doaj.org/toc/2041-1723Unwanted interactions between cellular components can complicate rational engineering of biological systems. Here the authors design insulated minimal promoters and operators that enable biophysical modeling of bacterial transcription without free parameters for precise circuit design.Yeqing ZongHaoqian M. ZhangCheng LyuXiangyu JiJunran HouXian GuoQi OuyangChunbo LouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yeqing Zong Haoqian M. Zhang Cheng Lyu Xiangyu Ji Junran Hou Xian Guo Qi Ouyang Chunbo Lou Insulated transcriptional elements enable precise design of genetic circuits
description	Unwanted interactions between cellular components can complicate rational engineering of biological systems. Here the authors design insulated minimal promoters and operators that enable biophysical modeling of bacterial transcription without free parameters for precise circuit design.
format	article
author	Yeqing Zong Haoqian M. Zhang Cheng Lyu Xiangyu Ji Junran Hou Xian Guo Qi Ouyang Chunbo Lou
author_facet	Yeqing Zong Haoqian M. Zhang Cheng Lyu Xiangyu Ji Junran Hou Xian Guo Qi Ouyang Chunbo Lou
author_sort	Yeqing Zong
title	Insulated transcriptional elements enable precise design of genetic circuits
title_short	Insulated transcriptional elements enable precise design of genetic circuits
title_full	Insulated transcriptional elements enable precise design of genetic circuits
title_fullStr	Insulated transcriptional elements enable precise design of genetic circuits
title_full_unstemmed	Insulated transcriptional elements enable precise design of genetic circuits
title_sort	insulated transcriptional elements enable precise design of genetic circuits
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3e5ebc6575034de280e65ca0e1e373fd
work_keys_str_mv	AT yeqingzong insulatedtranscriptionalelementsenableprecisedesignofgeneticcircuits AT haoqianmzhang insulatedtranscriptionalelementsenableprecisedesignofgeneticcircuits AT chenglyu insulatedtranscriptionalelementsenableprecisedesignofgeneticcircuits AT xiangyuji insulatedtranscriptionalelementsenableprecisedesignofgeneticcircuits AT junranhou insulatedtranscriptionalelementsenableprecisedesignofgeneticcircuits AT xianguo insulatedtranscriptionalelementsenableprecisedesignofgeneticcircuits AT qiouyang insulatedtranscriptionalelementsenableprecisedesignofgeneticcircuits AT chunbolou insulatedtranscriptionalelementsenableprecisedesignofgeneticcircuits
_version_	1718392969919201280

Insulated transcriptional elements enable precise design of genetic circuits

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