Cognitive performance and the thymus among HIV-infected subjects receiving HAART

Maria J Miguez-Burbano1, John E Lewis2, Jose Moreno3, Joel Fishman41Robert Stempel School of Public Health &amp; School of Medicine, Florida International University, Miami, FL, USA; 2Department of Psychiatry and Behavioral Sciences, 3Department of Medicine, 4Department of Radiology, Univers...

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Autores principales:	Maria J Miguez-Burbano, John E Lewis, Jose Moreno, Joel Fishman
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3e624f97d63c420f9e083b26bc73e4aa
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spelling	oai:doaj.org-article:3e624f97d63c420f9e083b26bc73e4aa2021-12-02T00:09:09ZCognitive performance and the thymus among HIV-infected subjects receiving HAART1177-54751177-5491https://doaj.org/article/3e624f97d63c420f9e083b26bc73e4aa2008-06-01T00:00:00Zhttp://www.dovepress.com/cognitive-performance-and-the-thymus-among-hiv-infected-subjects-recei-a1738https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Maria J Miguez-Burbano1, John E Lewis2, Jose Moreno3, Joel Fishman41Robert Stempel School of Public Health &amp; School of Medicine, Florida International University, Miami, FL, USA; 2Department of Psychiatry and Behavioral Sciences, 3Department of Medicine, 4Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USAObjective: To evaluate the impact of alcohol use, which is widespread in human immunodeficiency virus (HIV)+ individuals, on highly active antiretroviral therapy (HAART)-associated immune and cognitive improvements and the relationship between those two responses.Methods: In a case-control longitudinal study, thymic volume, cognition, and immune responses were evaluated at baseline and after 6 months therapy in HIV+ and HIV- controls. Cognitive performance was evaluated using the HIV Dementia Score (HDS) and the California Verbal Learning Test (CVLT).Results: Prior to HAART, thymic volume varied considerably from 2.7 to 29.3 cm3 (11 &plusmn; 7.2 cm3). Thymic volume at baseline showed a significantly inverse correlation with the patient&rsquo;s number of years of drinking (r2 = 0.207; p &lt; 0.01), as well as HDS and the CVLT scores in both HIV-infected (r2 = 0.37, p = 0.03) and noninfected (r2 = 0.8, p = 0.01). HIV-infected individuals with a small thymic volume scored in the demented range, as compared with those with a larger thymus (7 &plusmn; 2.7 vs. 12 &plusmn; 2.3, p = 0.005). After HAART, light/moderate drinkers exhibited thymus size twice that of heavy drinkers (14.8 &plusmn; 10.4 vs. 6.9 &plusmn; 3.3 cm3).Conclusions: HAART-associated increases of thymus volume appear to be negatively affected by alcohol consumption and significantly related to their cognitive status. This result could have important clinical implications.Keywords: thymus, CNS, immune, alcohol Maria J Miguez-BurbanoJohn E LewisJose MorenoJoel FishmanDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 2, Pp 321-327 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Maria J Miguez-Burbano John E Lewis Jose Moreno Joel Fishman Cognitive performance and the thymus among HIV-infected subjects receiving HAART
description	Maria J Miguez-Burbano1, John E Lewis2, Jose Moreno3, Joel Fishman41Robert Stempel School of Public Health &amp; School of Medicine, Florida International University, Miami, FL, USA; 2Department of Psychiatry and Behavioral Sciences, 3Department of Medicine, 4Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USAObjective: To evaluate the impact of alcohol use, which is widespread in human immunodeficiency virus (HIV)+ individuals, on highly active antiretroviral therapy (HAART)-associated immune and cognitive improvements and the relationship between those two responses.Methods: In a case-control longitudinal study, thymic volume, cognition, and immune responses were evaluated at baseline and after 6 months therapy in HIV+ and HIV- controls. Cognitive performance was evaluated using the HIV Dementia Score (HDS) and the California Verbal Learning Test (CVLT).Results: Prior to HAART, thymic volume varied considerably from 2.7 to 29.3 cm3 (11 &plusmn; 7.2 cm3). Thymic volume at baseline showed a significantly inverse correlation with the patient&rsquo;s number of years of drinking (r2 = 0.207; p &lt; 0.01), as well as HDS and the CVLT scores in both HIV-infected (r2 = 0.37, p = 0.03) and noninfected (r2 = 0.8, p = 0.01). HIV-infected individuals with a small thymic volume scored in the demented range, as compared with those with a larger thymus (7 &plusmn; 2.7 vs. 12 &plusmn; 2.3, p = 0.005). After HAART, light/moderate drinkers exhibited thymus size twice that of heavy drinkers (14.8 &plusmn; 10.4 vs. 6.9 &plusmn; 3.3 cm3).Conclusions: HAART-associated increases of thymus volume appear to be negatively affected by alcohol consumption and significantly related to their cognitive status. This result could have important clinical implications.Keywords: thymus, CNS, immune, alcohol
format	article
author	Maria J Miguez-Burbano John E Lewis Jose Moreno Joel Fishman
author_facet	Maria J Miguez-Burbano John E Lewis Jose Moreno Joel Fishman
author_sort	Maria J Miguez-Burbano
title	Cognitive performance and the thymus among HIV-infected subjects receiving HAART
title_short	Cognitive performance and the thymus among HIV-infected subjects receiving HAART
title_full	Cognitive performance and the thymus among HIV-infected subjects receiving HAART
title_fullStr	Cognitive performance and the thymus among HIV-infected subjects receiving HAART
title_full_unstemmed	Cognitive performance and the thymus among HIV-infected subjects receiving HAART
title_sort	cognitive performance and the thymus among hiv-infected subjects receiving haart
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/3e624f97d63c420f9e083b26bc73e4aa
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Cognitive performance and the thymus among HIV-infected subjects receiving HAART

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