Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine

To enter the cells, nanomaterials often need covalent conjugation with cell-penetrating ligands such as TAT. Here, the authors show that simple mixing with TAT-coupled nanoparticles enables the cellular uptake of unfunctionalized nanoparticles, and its activity is stimulated by cysteine in the mediu...

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Autores principales:	Yushuang Wei, Tang Tang, Hong-Bo Pang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e63d8a3837b46db9cd9f21f2d23320a
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spelling	oai:doaj.org-article:3e63d8a3837b46db9cd9f21f2d23320a2021-12-02T17:01:46ZCellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine10.1038/s41467-019-11631-w2041-1723https://doaj.org/article/3e63d8a3837b46db9cd9f21f2d23320a2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11631-whttps://doaj.org/toc/2041-1723To enter the cells, nanomaterials often need covalent conjugation with cell-penetrating ligands such as TAT. Here, the authors show that simple mixing with TAT-coupled nanoparticles enables the cellular uptake of unfunctionalized nanoparticles, and its activity is stimulated by cysteine in the medium.Yushuang WeiTang TangHong-Bo PangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yushuang Wei Tang Tang Hong-Bo Pang Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine
description	To enter the cells, nanomaterials often need covalent conjugation with cell-penetrating ligands such as TAT. Here, the authors show that simple mixing with TAT-coupled nanoparticles enables the cellular uptake of unfunctionalized nanoparticles, and its activity is stimulated by cysteine in the medium.
format	article
author	Yushuang Wei Tang Tang Hong-Bo Pang
author_facet	Yushuang Wei Tang Tang Hong-Bo Pang
author_sort	Yushuang Wei
title	Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine
title_short	Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine
title_full	Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine
title_fullStr	Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine
title_full_unstemmed	Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine
title_sort	cellular internalization of bystander nanomaterial induced by tat-nanoparticles and regulated by extracellular cysteine
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3e63d8a3837b46db9cd9f21f2d23320a
work_keys_str_mv	AT yushuangwei cellularinternalizationofbystandernanomaterialinducedbytatnanoparticlesandregulatedbyextracellularcysteine AT tangtang cellularinternalizationofbystandernanomaterialinducedbytatnanoparticlesandregulatedbyextracellularcysteine AT hongbopang cellularinternalizationofbystandernanomaterialinducedbytatnanoparticlesandregulatedbyextracellularcysteine
_version_	1718382022653640704

Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine

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