Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2

Abstract A pathogen inactivation step during collection or processing of clinical samples has the potential to reduce infectious risks associated with diagnostic procedures. It is essential that these inactivation methods are demonstrated to be effective, particularly for non-traditional inactivatio...

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Autores principales:	Katherine Davies, Ulrike Arnold, Hubert Buczkowski, Christopher Burton, Stephen R. Welch, Nicole Green, Rhea Strachan, Tracy Beetar-King, Peter Spencer, Nipunadi Hettiarachchi, Matthew J. Hannah, Matthew Jones, Patricia A. Cane, Christine B. Bruce, Neil Woodford, Allen D. G. Roberts, Marian J. Killip
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e64d64e5ccb421ebe31842603e18bbf
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spelling	oai:doaj.org-article:3e64d64e5ccb421ebe31842603e18bbf2021-12-05T12:15:01ZVirucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-210.1038/s41598-021-02942-42045-2322https://doaj.org/article/3e64d64e5ccb421ebe31842603e18bbf2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02942-4https://doaj.org/toc/2045-2322Abstract A pathogen inactivation step during collection or processing of clinical samples has the potential to reduce infectious risks associated with diagnostic procedures. It is essential that these inactivation methods are demonstrated to be effective, particularly for non-traditional inactivation reagents or for commercial products where the chemical composition is undisclosed. This study assessed inactivation effectiveness of twenty-four next-generation (guanidine-free) nucleic acid extraction lysis buffers and twelve rapid antigen test buffers against SARS-CoV-2, the causative agent of COVID-19. These data have significant safety implications for SARS-CoV-2 diagnostic testing and support the design and evidence-based risk assessment of these procedures.Katherine DaviesUlrike ArnoldHubert BuczkowskiChristopher BurtonStephen R. WelchNicole GreenRhea StrachanTracy Beetar-KingPeter SpencerNipunadi HettiarachchiMatthew J. HannahMatthew JonesPatricia A. CaneChristine B. BruceNeil WoodfordAllen D. G. RobertsMarian J. KillipNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katherine Davies Ulrike Arnold Hubert Buczkowski Christopher Burton Stephen R. Welch Nicole Green Rhea Strachan Tracy Beetar-King Peter Spencer Nipunadi Hettiarachchi Matthew J. Hannah Matthew Jones Patricia A. Cane Christine B. Bruce Neil Woodford Allen D. G. Roberts Marian J. Killip Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2
description	Abstract A pathogen inactivation step during collection or processing of clinical samples has the potential to reduce infectious risks associated with diagnostic procedures. It is essential that these inactivation methods are demonstrated to be effective, particularly for non-traditional inactivation reagents or for commercial products where the chemical composition is undisclosed. This study assessed inactivation effectiveness of twenty-four next-generation (guanidine-free) nucleic acid extraction lysis buffers and twelve rapid antigen test buffers against SARS-CoV-2, the causative agent of COVID-19. These data have significant safety implications for SARS-CoV-2 diagnostic testing and support the design and evidence-based risk assessment of these procedures.
format	article
author	Katherine Davies Ulrike Arnold Hubert Buczkowski Christopher Burton Stephen R. Welch Nicole Green Rhea Strachan Tracy Beetar-King Peter Spencer Nipunadi Hettiarachchi Matthew J. Hannah Matthew Jones Patricia A. Cane Christine B. Bruce Neil Woodford Allen D. G. Roberts Marian J. Killip
author_facet	Katherine Davies Ulrike Arnold Hubert Buczkowski Christopher Burton Stephen R. Welch Nicole Green Rhea Strachan Tracy Beetar-King Peter Spencer Nipunadi Hettiarachchi Matthew J. Hannah Matthew Jones Patricia A. Cane Christine B. Bruce Neil Woodford Allen D. G. Roberts Marian J. Killip
author_sort	Katherine Davies
title	Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2
title_short	Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2
title_full	Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2
title_fullStr	Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2
title_full_unstemmed	Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2
title_sort	virucidal efficacy of guanidine-free inactivants and rapid test buffers against sars-cov-2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e64d64e5ccb421ebe31842603e18bbf
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Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2

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