Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation
Abstract To reduce the ambiguity of contradictory observations in different studies regarding the expression level of Macrophage Inhibitory Cytokine-1 (MIC-1) in serum in prostate cancer (PC), benign prostatic hyperplasia (BPH) and healthy controls (HC), we designed this double-blind study. The stud...
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oai:doaj.org-article:3e65acf04b32411595ca1468f35a97f22021-12-02T15:04:53ZRelevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation10.1038/s41598-017-17207-22045-2322https://doaj.org/article/3e65acf04b32411595ca1468f35a97f22017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-17207-2https://doaj.org/toc/2045-2322Abstract To reduce the ambiguity of contradictory observations in different studies regarding the expression level of Macrophage Inhibitory Cytokine-1 (MIC-1) in serum in prostate cancer (PC), benign prostatic hyperplasia (BPH) and healthy controls (HC), we designed this double-blind study. The study comprises 240 sera from PC, BPH and HC subjects. The expression level of MIC-1 in PC, BPH and HC were appraised using Western blot (WB) and ELISA based approach. WB and ELISA appraisal reveals that the expression level of MIC-1 is significantly higher in PC than in HC or BPH subjects. Regression analysis revealed a significant correlation between MIC-1 vs. PSA (r = 0.09; p < 0.001) and MIC-1 vs. GS (r = 0.7; p < 0.001). ROC analysis using discriminant predicted probability revealed that the MIC-1 was better than PSA. Moreover, the combination of MIC-1 and PSA was allowing 99.1% AUC for the differentiation of BPH + PC from HC, 97.9% AUC for differentiation of BPH from HC, 98.6% AUC for differentiation of PC from HC, and 96.7% AUC for the differentiation of PC from BPH. The augmented expression of MIC-1 in PC compared to BPH and HC subjects is in concurrent of the over-expression of MIC-1 in PC reports and confiscates the contradictory findings of other studies.Navneeta BansalDeepak KumarAshish GuptaDeepak ChandraSatya Narain SankhwarAnil MandhaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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Medicine R Science Q Navneeta Bansal Deepak Kumar Ashish Gupta Deepak Chandra Satya Narain Sankhwar Anil Mandhani Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation |
| description |
Abstract To reduce the ambiguity of contradictory observations in different studies regarding the expression level of Macrophage Inhibitory Cytokine-1 (MIC-1) in serum in prostate cancer (PC), benign prostatic hyperplasia (BPH) and healthy controls (HC), we designed this double-blind study. The study comprises 240 sera from PC, BPH and HC subjects. The expression level of MIC-1 in PC, BPH and HC were appraised using Western blot (WB) and ELISA based approach. WB and ELISA appraisal reveals that the expression level of MIC-1 is significantly higher in PC than in HC or BPH subjects. Regression analysis revealed a significant correlation between MIC-1 vs. PSA (r = 0.09; p < 0.001) and MIC-1 vs. GS (r = 0.7; p < 0.001). ROC analysis using discriminant predicted probability revealed that the MIC-1 was better than PSA. Moreover, the combination of MIC-1 and PSA was allowing 99.1% AUC for the differentiation of BPH + PC from HC, 97.9% AUC for differentiation of BPH from HC, 98.6% AUC for differentiation of PC from HC, and 96.7% AUC for the differentiation of PC from BPH. The augmented expression of MIC-1 in PC compared to BPH and HC subjects is in concurrent of the over-expression of MIC-1 in PC reports and confiscates the contradictory findings of other studies. |
| format |
article |
| author |
Navneeta Bansal Deepak Kumar Ashish Gupta Deepak Chandra Satya Narain Sankhwar Anil Mandhani |
| author_facet |
Navneeta Bansal Deepak Kumar Ashish Gupta Deepak Chandra Satya Narain Sankhwar Anil Mandhani |
| author_sort |
Navneeta Bansal |
| title |
Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation |
| title_short |
Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation |
| title_full |
Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation |
| title_fullStr |
Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation |
| title_full_unstemmed |
Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation |
| title_sort |
relevance of mic-1 in the era of psa as a serum based predictor of prostate cancer: a critical evaluation |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/3e65acf04b32411595ca1468f35a97f2 |
| work_keys_str_mv |
AT navneetabansal relevanceofmic1intheeraofpsaasaserumbasedpredictorofprostatecanceracriticalevaluation AT deepakkumar relevanceofmic1intheeraofpsaasaserumbasedpredictorofprostatecanceracriticalevaluation AT ashishgupta relevanceofmic1intheeraofpsaasaserumbasedpredictorofprostatecanceracriticalevaluation AT deepakchandra relevanceofmic1intheeraofpsaasaserumbasedpredictorofprostatecanceracriticalevaluation AT satyanarainsankhwar relevanceofmic1intheeraofpsaasaserumbasedpredictorofprostatecanceracriticalevaluation AT anilmandhani relevanceofmic1intheeraofpsaasaserumbasedpredictorofprostatecanceracriticalevaluation |
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