Transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer

Abstract Primary cancer cells exert unique capacity to disseminate and nestle in distant organs. Once seeded in secondary sites, cancer cells may enter a dormant state, becoming resistant to current treatment approaches, and they remain silent until they reactivate and cause overt metastases. To ill...

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Autores principales:	Dilara Uzuner, Yunus Akkoç, Nesibe Peker, Pınar Pir, Devrim Gözüaçık, Tunahan Çakır
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e685cae02274edbaadafc3622cb10e0
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spelling	oai:doaj.org-article:3e685cae02274edbaadafc3622cb10e02021-12-02T17:06:10ZTranscriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer10.1038/s41598-021-94005-x2045-2322https://doaj.org/article/3e685cae02274edbaadafc3622cb10e02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94005-xhttps://doaj.org/toc/2045-2322Abstract Primary cancer cells exert unique capacity to disseminate and nestle in distant organs. Once seeded in secondary sites, cancer cells may enter a dormant state, becoming resistant to current treatment approaches, and they remain silent until they reactivate and cause overt metastases. To illuminate the complex mechanisms of cancer dormancy, 10 transcriptomic datasets from the literature enabling 21 dormancy–cancer comparisons were mapped on protein–protein interaction networks and gene-regulatory networks to extract subnetworks that are enriched in significantly deregulated genes. The genes appearing in the subnetworks and significantly upregulated in dormancy with respect to proliferative state were scored and filtered across all comparisons, leading to a dormancy–interaction network for the first time in the literature, which includes 139 genes and 1974 interactions. The dormancy interaction network will contribute to the elucidation of cellular mechanisms orchestrating cancer dormancy, paving the way for improvements in the diagnosis and treatment of metastatic cancer.Dilara UzunerYunus AkkoçNesibe PekerPınar PirDevrim GözüaçıkTunahan ÇakırNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dilara Uzuner Yunus Akkoç Nesibe Peker Pınar Pir Devrim Gözüaçık Tunahan Çakır Transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer
description	Abstract Primary cancer cells exert unique capacity to disseminate and nestle in distant organs. Once seeded in secondary sites, cancer cells may enter a dormant state, becoming resistant to current treatment approaches, and they remain silent until they reactivate and cause overt metastases. To illuminate the complex mechanisms of cancer dormancy, 10 transcriptomic datasets from the literature enabling 21 dormancy–cancer comparisons were mapped on protein–protein interaction networks and gene-regulatory networks to extract subnetworks that are enriched in significantly deregulated genes. The genes appearing in the subnetworks and significantly upregulated in dormancy with respect to proliferative state were scored and filtered across all comparisons, leading to a dormancy–interaction network for the first time in the literature, which includes 139 genes and 1974 interactions. The dormancy interaction network will contribute to the elucidation of cellular mechanisms orchestrating cancer dormancy, paving the way for improvements in the diagnosis and treatment of metastatic cancer.
format	article
author	Dilara Uzuner Yunus Akkoç Nesibe Peker Pınar Pir Devrim Gözüaçık Tunahan Çakır
author_facet	Dilara Uzuner Yunus Akkoç Nesibe Peker Pınar Pir Devrim Gözüaçık Tunahan Çakır
author_sort	Dilara Uzuner
title	Transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer
title_short	Transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer
title_full	Transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer
title_fullStr	Transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer
title_full_unstemmed	Transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer
title_sort	transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e685cae02274edbaadafc3622cb10e0
work_keys_str_mv	AT dilarauzuner transcriptionallandscapeofcellularnetworksrevealinteractionsdrivingthedormancymechanismsincancer AT yunusakkoc transcriptionallandscapeofcellularnetworksrevealinteractionsdrivingthedormancymechanismsincancer AT nesibepeker transcriptionallandscapeofcellularnetworksrevealinteractionsdrivingthedormancymechanismsincancer AT pınarpir transcriptionallandscapeofcellularnetworksrevealinteractionsdrivingthedormancymechanismsincancer AT devrimgozuacık transcriptionallandscapeofcellularnetworksrevealinteractionsdrivingthedormancymechanismsincancer AT tunahancakır transcriptionallandscapeofcellularnetworksrevealinteractionsdrivingthedormancymechanismsincancer
_version_	1718381724451209216

Transcriptional landscape of cellular networks reveal interactions driving the dormancy mechanisms in cancer

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