The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing

Splice isoform switching regulated by the heterogeneous nuclear ribonucleoprotein M (hnRNPM) induces EMT and metastasis. Here, the authors report that AKAP8 is a metastasis suppressor that inhibits the splicing activity of hnRNPM and antagonizes genome-wide EMT-associated alternative splicing to mai...

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Autores principales:	Xiaohui Hu, Samuel E. Harvey, Rong Zheng, Jingyi Lyu, Caitlin L. Grzeskowiak, Emily Powell, Helen Piwnica-Worms, Kenneth L. Scott, Chonghui Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e6d53a010c24e5a8bea23bdcf82f99b
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spelling	oai:doaj.org-article:3e6d53a010c24e5a8bea23bdcf82f99b2021-12-02T17:31:11ZThe RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing10.1038/s41467-020-14304-12041-1723https://doaj.org/article/3e6d53a010c24e5a8bea23bdcf82f99b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14304-1https://doaj.org/toc/2041-1723Splice isoform switching regulated by the heterogeneous nuclear ribonucleoprotein M (hnRNPM) induces EMT and metastasis. Here, the authors report that AKAP8 is a metastasis suppressor that inhibits the splicing activity of hnRNPM and antagonizes genome-wide EMT-associated alternative splicing to maintain epithelial cell state.Xiaohui HuSamuel E. HarveyRong ZhengJingyi LyuCaitlin L. GrzeskowiakEmily PowellHelen Piwnica-WormsKenneth L. ScottChonghui ChengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaohui Hu Samuel E. Harvey Rong Zheng Jingyi Lyu Caitlin L. Grzeskowiak Emily Powell Helen Piwnica-Worms Kenneth L. Scott Chonghui Cheng The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
description	Splice isoform switching regulated by the heterogeneous nuclear ribonucleoprotein M (hnRNPM) induces EMT and metastasis. Here, the authors report that AKAP8 is a metastasis suppressor that inhibits the splicing activity of hnRNPM and antagonizes genome-wide EMT-associated alternative splicing to maintain epithelial cell state.
format	article
author	Xiaohui Hu Samuel E. Harvey Rong Zheng Jingyi Lyu Caitlin L. Grzeskowiak Emily Powell Helen Piwnica-Worms Kenneth L. Scott Chonghui Cheng
author_facet	Xiaohui Hu Samuel E. Harvey Rong Zheng Jingyi Lyu Caitlin L. Grzeskowiak Emily Powell Helen Piwnica-Worms Kenneth L. Scott Chonghui Cheng
author_sort	Xiaohui Hu
title	The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
title_short	The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
title_full	The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
title_fullStr	The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
title_full_unstemmed	The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
title_sort	rna-binding protein akap8 suppresses tumor metastasis by antagonizing emt-associated alternative splicing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3e6d53a010c24e5a8bea23bdcf82f99b
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The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing

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