Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

The molecular mechanisms underlying cardiac chamber formation are not well understood. Here, the authors show that planar cell polarity signalling through Wnt5b and Wnt11 coordinates localised and tissue-scale polarised actomyosin contractility in the zebrafish heart, regulating cardiac chamber form...

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Autores principales:	Anne Margarete Merks, Marie Swinarski, Alexander Matthias Meyer, Nicola Victoria Müller, Ismail Özcan, Stefan Donat, Alexa Burger, Stephen Gilbert, Christian Mosimann, Salim Abdelilah-Seyfried, Daniela Panáková
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e6df84b48be483bbf76b4b5ec7606cd
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spelling	oai:doaj.org-article:3e6df84b48be483bbf76b4b5ec7606cd2021-12-02T17:31:43ZPlanar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity10.1038/s41467-018-04566-12041-1723https://doaj.org/article/3e6df84b48be483bbf76b4b5ec7606cd2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04566-1https://doaj.org/toc/2041-1723The molecular mechanisms underlying cardiac chamber formation are not well understood. Here, the authors show that planar cell polarity signalling through Wnt5b and Wnt11 coordinates localised and tissue-scale polarised actomyosin contractility in the zebrafish heart, regulating cardiac chamber formation and looping.Anne Margarete MerksMarie SwinarskiAlexander Matthias MeyerNicola Victoria MüllerIsmail ÖzcanStefan DonatAlexa BurgerStephen GilbertChristian MosimannSalim Abdelilah-SeyfriedDaniela PanákováNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne Margarete Merks Marie Swinarski Alexander Matthias Meyer Nicola Victoria Müller Ismail Özcan Stefan Donat Alexa Burger Stephen Gilbert Christian Mosimann Salim Abdelilah-Seyfried Daniela Panáková Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
description	The molecular mechanisms underlying cardiac chamber formation are not well understood. Here, the authors show that planar cell polarity signalling through Wnt5b and Wnt11 coordinates localised and tissue-scale polarised actomyosin contractility in the zebrafish heart, regulating cardiac chamber formation and looping.
format	article
author	Anne Margarete Merks Marie Swinarski Alexander Matthias Meyer Nicola Victoria Müller Ismail Özcan Stefan Donat Alexa Burger Stephen Gilbert Christian Mosimann Salim Abdelilah-Seyfried Daniela Panáková
author_facet	Anne Margarete Merks Marie Swinarski Alexander Matthias Meyer Nicola Victoria Müller Ismail Özcan Stefan Donat Alexa Burger Stephen Gilbert Christian Mosimann Salim Abdelilah-Seyfried Daniela Panáková
author_sort	Anne Margarete Merks
title	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_short	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_full	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_fullStr	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_full_unstemmed	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_sort	planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3e6df84b48be483bbf76b4b5ec7606cd
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Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

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