Women born preterm or with inappropriate weight for gestational age are at risk of subsequent gestational diabetes and pre-eclampsia.
<h4>Introduction</h4>Low birthweight, which can be caused by inappropriate intrauterine growth or prematurity, is associated with development of gestational diabetes mellitus (GDM) as well as pre-eclampsia later in life, but the relative effects of prematurity and inappropriate intrauter...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3e74dfee95cc478e8abb25947d9df9fa |
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| Sumario: | <h4>Introduction</h4>Low birthweight, which can be caused by inappropriate intrauterine growth or prematurity, is associated with development of gestational diabetes mellitus (GDM) as well as pre-eclampsia later in life, but the relative effects of prematurity and inappropriate intrauterine growth remain uncertain.<h4>Methods</h4>Through nation-wide registries we identified all Danish mothers in the years 1989-2007. Two separate cohorts consisting mothers born 1974-1977 (n = 84219) and 1978-1981 (n = 32376) were studied, due to different methods of registering birthweight and gestational age in the two periods. Data was linked with information on GDM, pre-eclampsia and education.<h4>Results</h4>In a multivariate logistic regression model the odds of developing GDM was increased by 5-7% for each week the mother was born before term (p = 0.018 for 1974-1977, p = 0.048 for 1978-1981), while the odds were increased by 13-17% for each standard deviation (SD) reduction in birthweight for gestational age for those who were small or normal for gestational age (p<0.0001 and p = 0.035) and increased by 118-122% for each SD increase above the normal range (p<0.0001 and p = 0.024). The odds of pre-eclampsia was increased by 3-5% for each week the mother was born before term (p = 0.064 and p = 0.04), while the odds were increased 11-12% for each SD reduction in birthweight for gestational age (p<0.0001 and p = 0.0002).<h4>Conclusion</h4>In this cohort of young Danish mothers, being born premature or with increasingly low birthweight for gestational age was associated with an increased risk of GDM and pre-eclampsia in adulthood, while increasingly high birthweight for gestational age was associated with an increased risk of GDM and a decreased risk of pre-eclampsia. Inappropriate weight for gestational age was a more important risk factor than prematurity. |
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