Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity

Abstract Human induced pluripotent stem (iPS) cell technologies coupled with genetic engineering now facilitate the study of the molecular underpinnings of disease in relevant human cell types. Application of CRISPR/Cas9-based approaches for genome-scale functional screening in iPS-derived cells, ho...

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Bibliographic Details
Main Authors: Valerie Sapp, Aitor Aguirre, Gayatri Mainkar, Jeffrey Ding, Eric Adler, Ronglih Liao, Sonia Sharma, Mohit Jain
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/3e7b6bbe20104376830c9ac969a7c0df
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