Transient genome-wide interactions of the master transcription factor NLP7 initiate a rapid nitrogen-response cascade

Conventional methods cannot reveal transient transcription factors (TFs) and targets interactions. Here, Alvarez et al. capture both stable and transient TF-target interactions by time-series ChIP-seq and/or DamID-seq in a cell-based TF perturbation system and show NLP7 as a master TF to initiate a...

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Autores principales: José M. Alvarez, Anna-Lena Schinke, Matthew D. Brooks, Angelo Pasquino, Lauriebeth Leonelli, Kranthi Varala, Alaeddine Safi, Gabriel Krouk, Anne Krapp, Gloria M. Coruzzi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3e7c1767b2d34c089055f0b932128ac5
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Sumario:Conventional methods cannot reveal transient transcription factors (TFs) and targets interactions. Here, Alvarez et al. capture both stable and transient TF-target interactions by time-series ChIP-seq and/or DamID-seq in a cell-based TF perturbation system and show NLP7 as a master TF to initiate a rapid nitrogen-response cascade.