Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

Glucosamine (GlcN) is the most widely consumed dietary supplement and exhibits anti-inflammatory effects. However, the influence of GlcN on immune cell generation and function is largely unclear. In this study, GlcN was delivered into mice to examine its biological function in hematopoiesis. We foun...

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Autores principales:	Eric Chang-Yi Lin, Shuoh-Wen Chen, Luen-Kui Chen, Ting-An Lin, Yu-Xuan Wu, Chi-Chang Juan, Yuan-I Chang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	d-Glucosamine hydrochloride (PubChem CID: 91431) hematopoietic stem cell (HSC) myelopoiesis myeloid-derived suppressive cell immunosuppression Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/3e8850494408446d945e2a47e595d020
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spelling	oai:doaj.org-article:3e8850494408446d945e2a47e595d0202021-11-10T06:17:07ZGlucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells2296-861X10.3389/fnut.2021.762363https://doaj.org/article/3e8850494408446d945e2a47e595d0202021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.762363/fullhttps://doaj.org/toc/2296-861XGlucosamine (GlcN) is the most widely consumed dietary supplement and exhibits anti-inflammatory effects. However, the influence of GlcN on immune cell generation and function is largely unclear. In this study, GlcN was delivered into mice to examine its biological function in hematopoiesis. We found that GlcN promoted the production of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs), both in vivo and in vitro. Additionally, GlcN upregulated the expression of glucose transporter 1 in hematopoietic stem and progenitor cells (HSPCs), influenced HSPC functions, and downregulated key genes involved in myelopoiesis. Furthermore, GlcN increased the expression of arginase 1 and inducible nitric oxide synthase to produce high levels of reactive oxygen species, which was regulated by the STAT3 and ERK1/2 pathways, to increase the immunosuppressive ability of MDSCs. We revealed a novel role for GlcN in myelopoiesis and MDSC activity involving a potential link between GlcN and immune system, as well as the new therapeutic benefit.Eric Chang-Yi LinShuoh-Wen ChenLuen-Kui ChenTing-An LinTing-An LinTing-An LinYu-Xuan WuChi-Chang JuanYuan-I ChangFrontiers Media S.A.articled-Glucosamine hydrochloride (PubChem CID: 91431)hematopoietic stem cell (HSC)myelopoiesismyeloid-derived suppressive cellimmunosuppressionNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	d-Glucosamine hydrochloride (PubChem CID: 91431) hematopoietic stem cell (HSC) myelopoiesis myeloid-derived suppressive cell immunosuppression Nutrition. Foods and food supply TX341-641
spellingShingle	d-Glucosamine hydrochloride (PubChem CID: 91431) hematopoietic stem cell (HSC) myelopoiesis myeloid-derived suppressive cell immunosuppression Nutrition. Foods and food supply TX341-641 Eric Chang-Yi Lin Shuoh-Wen Chen Luen-Kui Chen Ting-An Lin Ting-An Lin Ting-An Lin Yu-Xuan Wu Chi-Chang Juan Yuan-I Chang Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
description	Glucosamine (GlcN) is the most widely consumed dietary supplement and exhibits anti-inflammatory effects. However, the influence of GlcN on immune cell generation and function is largely unclear. In this study, GlcN was delivered into mice to examine its biological function in hematopoiesis. We found that GlcN promoted the production of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs), both in vivo and in vitro. Additionally, GlcN upregulated the expression of glucose transporter 1 in hematopoietic stem and progenitor cells (HSPCs), influenced HSPC functions, and downregulated key genes involved in myelopoiesis. Furthermore, GlcN increased the expression of arginase 1 and inducible nitric oxide synthase to produce high levels of reactive oxygen species, which was regulated by the STAT3 and ERK1/2 pathways, to increase the immunosuppressive ability of MDSCs. We revealed a novel role for GlcN in myelopoiesis and MDSC activity involving a potential link between GlcN and immune system, as well as the new therapeutic benefit.
format	article
author	Eric Chang-Yi Lin Shuoh-Wen Chen Luen-Kui Chen Ting-An Lin Ting-An Lin Ting-An Lin Yu-Xuan Wu Chi-Chang Juan Yuan-I Chang
author_facet	Eric Chang-Yi Lin Shuoh-Wen Chen Luen-Kui Chen Ting-An Lin Ting-An Lin Ting-An Lin Yu-Xuan Wu Chi-Chang Juan Yuan-I Chang
author_sort	Eric Chang-Yi Lin
title	Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
title_short	Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
title_full	Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
title_fullStr	Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
title_full_unstemmed	Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
title_sort	glucosamine interferes with myelopoiesis and enhances the immunosuppressive activity of myeloid-derived suppressor cells
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3e8850494408446d945e2a47e595d020
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Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

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