Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy

Rap1 is a telomeric protein that is highly expressed in cancers. Here, the authors show that Rap1 interacts with several DNA repair proteins independent of its telomere function to enhance DNA repair and that its deficiency leads to accelerated tumorigenesis, but enhanced sensitivity to genotoxic st...

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Autores principales:	Ekta Khattar, Kyaw Ze Ya Maung, Chen Li Chew, Arkasubhra Ghosh, Michelle Meng Huang Mok, Pei Lee, Jun Zhang, Wei Hong Jeff Chor, Gökhan Cildir, Chelsia Qiuxia Wang, Nur Khairiah Mohd-Ismail, Desmond Wai Loon Chin, Soo Chin Lee, Henry Yang, Yong-Jae Shin, Do-Hyun Nam, Liming Chen, Alan Prem Kumar, Lih Wen Deng, Masahito Ikawa, Jayantha Gunaratne, Motomi Osato, Vinay Tergaonkar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e889e3b0c2349c59ada25c89786da9e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:3e889e3b0c2349c59ada25c89786da9e2021-12-02T17:02:14ZRap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy10.1038/s41467-019-13082-92041-1723https://doaj.org/article/3e889e3b0c2349c59ada25c89786da9e2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13082-9https://doaj.org/toc/2041-1723Rap1 is a telomeric protein that is highly expressed in cancers. Here, the authors show that Rap1 interacts with several DNA repair proteins independent of its telomere function to enhance DNA repair and that its deficiency leads to accelerated tumorigenesis, but enhanced sensitivity to genotoxic stress.Ekta KhattarKyaw Ze Ya MaungChen Li ChewArkasubhra GhoshMichelle Meng Huang MokPei LeeJun ZhangWei Hong Jeff ChorGökhan CildirChelsia Qiuxia WangNur Khairiah Mohd-IsmailDesmond Wai Loon ChinSoo Chin LeeHenry YangYong-Jae ShinDo-Hyun NamLiming ChenAlan Prem KumarLih Wen DengMasahito IkawaJayantha GunaratneMotomi OsatoVinay TergaonkarNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ekta Khattar Kyaw Ze Ya Maung Chen Li Chew Arkasubhra Ghosh Michelle Meng Huang Mok Pei Lee Jun Zhang Wei Hong Jeff Chor Gökhan Cildir Chelsia Qiuxia Wang Nur Khairiah Mohd-Ismail Desmond Wai Loon Chin Soo Chin Lee Henry Yang Yong-Jae Shin Do-Hyun Nam Liming Chen Alan Prem Kumar Lih Wen Deng Masahito Ikawa Jayantha Gunaratne Motomi Osato Vinay Tergaonkar Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
description	Rap1 is a telomeric protein that is highly expressed in cancers. Here, the authors show that Rap1 interacts with several DNA repair proteins independent of its telomere function to enhance DNA repair and that its deficiency leads to accelerated tumorigenesis, but enhanced sensitivity to genotoxic stress.
format	article
author	Ekta Khattar Kyaw Ze Ya Maung Chen Li Chew Arkasubhra Ghosh Michelle Meng Huang Mok Pei Lee Jun Zhang Wei Hong Jeff Chor Gökhan Cildir Chelsia Qiuxia Wang Nur Khairiah Mohd-Ismail Desmond Wai Loon Chin Soo Chin Lee Henry Yang Yong-Jae Shin Do-Hyun Nam Liming Chen Alan Prem Kumar Lih Wen Deng Masahito Ikawa Jayantha Gunaratne Motomi Osato Vinay Tergaonkar
author_facet	Ekta Khattar Kyaw Ze Ya Maung Chen Li Chew Arkasubhra Ghosh Michelle Meng Huang Mok Pei Lee Jun Zhang Wei Hong Jeff Chor Gökhan Cildir Chelsia Qiuxia Wang Nur Khairiah Mohd-Ismail Desmond Wai Loon Chin Soo Chin Lee Henry Yang Yong-Jae Shin Do-Hyun Nam Liming Chen Alan Prem Kumar Lih Wen Deng Masahito Ikawa Jayantha Gunaratne Motomi Osato Vinay Tergaonkar
author_sort	Ekta Khattar
title	Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
title_short	Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
title_full	Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
title_fullStr	Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
title_full_unstemmed	Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
title_sort	rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3e889e3b0c2349c59ada25c89786da9e
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Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy

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