ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

Damaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged with a toxin that induces mitochondrial damage.

Guardado en:

Detalles Bibliográficos
Autores principales:	Natalia Moskal, Victoria Riccio, Mikhail Bashkurov, Rediet Taddese, Alessandro Datti, Peter N. Lewis, G. Angus McQuibban
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e89b2ca7aa044dba87795668f0519b1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3e89b2ca7aa044dba87795668f0519b1
record_format	dspace
spelling	oai:doaj.org-article:3e89b2ca7aa044dba87795668f0519b12021-12-02T14:40:43ZROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway10.1038/s41467-019-13781-32041-1723https://doaj.org/article/3e89b2ca7aa044dba87795668f0519b12020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13781-3https://doaj.org/toc/2041-1723Damaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged with a toxin that induces mitochondrial damage.Natalia MoskalVictoria RiccioMikhail BashkurovRediet TaddeseAlessandro DattiPeter N. LewisG. Angus McQuibbanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Natalia Moskal Victoria Riccio Mikhail Bashkurov Rediet Taddese Alessandro Datti Peter N. Lewis G. Angus McQuibban ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
description	Damaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged with a toxin that induces mitochondrial damage.
format	article
author	Natalia Moskal Victoria Riccio Mikhail Bashkurov Rediet Taddese Alessandro Datti Peter N. Lewis G. Angus McQuibban
author_facet	Natalia Moskal Victoria Riccio Mikhail Bashkurov Rediet Taddese Alessandro Datti Peter N. Lewis G. Angus McQuibban
author_sort	Natalia Moskal
title	ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
title_short	ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
title_full	ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
title_fullStr	ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
title_full_unstemmed	ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
title_sort	rock inhibitors upregulate the neuroprotective parkin-mediated mitophagy pathway
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3e89b2ca7aa044dba87795668f0519b1
work_keys_str_mv	AT nataliamoskal rockinhibitorsupregulatetheneuroprotectiveparkinmediatedmitophagypathway AT victoriariccio rockinhibitorsupregulatetheneuroprotectiveparkinmediatedmitophagypathway AT mikhailbashkurov rockinhibitorsupregulatetheneuroprotectiveparkinmediatedmitophagypathway AT rediettaddese rockinhibitorsupregulatetheneuroprotectiveparkinmediatedmitophagypathway AT alessandrodatti rockinhibitorsupregulatetheneuroprotectiveparkinmediatedmitophagypathway AT peternlewis rockinhibitorsupregulatetheneuroprotectiveparkinmediatedmitophagypathway AT gangusmcquibban rockinhibitorsupregulatetheneuroprotectiveparkinmediatedmitophagypathway
_version_	1718390169029050368

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

Ejemplares similares