Photosensitizers Mediated Photodynamic Inactivation against Fungi

Superficial and systemic fungal infections are essential problems for the modern health care system. One of the challenges is the growing resistance of fungi to classic antifungals and the constantly increasing cost of therapy. These factors force the scientific world to intensify the search for alt...

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Autores principales:	Daniel Ziental, Dariusz T. Mlynarczyk, Beata Czarczynska-Goslinska, Konrad Lewandowski, Lukasz Sobotta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	macrocycle photocytotoxicity fungi photodynamic therapy infections Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/3e8a04656acc4a529fbd391fbfcdc9ae
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spelling	oai:doaj.org-article:3e8a04656acc4a529fbd391fbfcdc9ae2021-11-25T18:30:38ZPhotosensitizers Mediated Photodynamic Inactivation against Fungi10.3390/nano111128832079-4991https://doaj.org/article/3e8a04656acc4a529fbd391fbfcdc9ae2021-10-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2883https://doaj.org/toc/2079-4991Superficial and systemic fungal infections are essential problems for the modern health care system. One of the challenges is the growing resistance of fungi to classic antifungals and the constantly increasing cost of therapy. These factors force the scientific world to intensify the search for alternative and more effective methods of treatment. This paper presents an overview of new fungal inactivation methods using Photodynamic Antimicrobial Chemotherapy (PACT). The results of research on compounds from the groups of phenothiazines, xanthanes, porphyrins, chlorins, porphyrazines, and phthalocyanines are presented. An intensive search for a photosensitizer with excellent properties is currently underway. The formulation based on the existing ones is also developed by combining them with nanoparticles and common antifungal therapy. Numerous studies indicate that fungi do not form any specific defense mechanism against PACT, which deems it a promising therapeutic alternative.Daniel ZientalDariusz T. MlynarczykBeata Czarczynska-GoslinskaKonrad LewandowskiLukasz SobottaMDPI AGarticlemacrocyclephotocytotoxicityfungiphotodynamic therapyinfectionsChemistryQD1-999ENNanomaterials, Vol 11, Iss 2883, p 2883 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macrocycle photocytotoxicity fungi photodynamic therapy infections Chemistry QD1-999
spellingShingle	macrocycle photocytotoxicity fungi photodynamic therapy infections Chemistry QD1-999 Daniel Ziental Dariusz T. Mlynarczyk Beata Czarczynska-Goslinska Konrad Lewandowski Lukasz Sobotta Photosensitizers Mediated Photodynamic Inactivation against Fungi
description	Superficial and systemic fungal infections are essential problems for the modern health care system. One of the challenges is the growing resistance of fungi to classic antifungals and the constantly increasing cost of therapy. These factors force the scientific world to intensify the search for alternative and more effective methods of treatment. This paper presents an overview of new fungal inactivation methods using Photodynamic Antimicrobial Chemotherapy (PACT). The results of research on compounds from the groups of phenothiazines, xanthanes, porphyrins, chlorins, porphyrazines, and phthalocyanines are presented. An intensive search for a photosensitizer with excellent properties is currently underway. The formulation based on the existing ones is also developed by combining them with nanoparticles and common antifungal therapy. Numerous studies indicate that fungi do not form any specific defense mechanism against PACT, which deems it a promising therapeutic alternative.
format	article
author	Daniel Ziental Dariusz T. Mlynarczyk Beata Czarczynska-Goslinska Konrad Lewandowski Lukasz Sobotta
author_facet	Daniel Ziental Dariusz T. Mlynarczyk Beata Czarczynska-Goslinska Konrad Lewandowski Lukasz Sobotta
author_sort	Daniel Ziental
title	Photosensitizers Mediated Photodynamic Inactivation against Fungi
title_short	Photosensitizers Mediated Photodynamic Inactivation against Fungi
title_full	Photosensitizers Mediated Photodynamic Inactivation against Fungi
title_fullStr	Photosensitizers Mediated Photodynamic Inactivation against Fungi
title_full_unstemmed	Photosensitizers Mediated Photodynamic Inactivation against Fungi
title_sort	photosensitizers mediated photodynamic inactivation against fungi
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3e8a04656acc4a529fbd391fbfcdc9ae
work_keys_str_mv	AT danielziental photosensitizersmediatedphotodynamicinactivationagainstfungi AT dariusztmlynarczyk photosensitizersmediatedphotodynamicinactivationagainstfungi AT beataczarczynskagoslinska photosensitizersmediatedphotodynamicinactivationagainstfungi AT konradlewandowski photosensitizersmediatedphotodynamicinactivationagainstfungi AT lukaszsobotta photosensitizersmediatedphotodynamicinactivationagainstfungi
_version_	1718411069204987904

Photosensitizers Mediated Photodynamic Inactivation against Fungi

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