Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing

Diabetic foot ulcers (DFU) represent a complex disease with limited treatment options. Here, the authors compare human RNASeq patient data from DFU, oral mucosa and skin acute wounds, identifying FOXM1 as a mediator of macrophage and neutrophil recruitment, which contributes to disease pathogenesis...

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Autores principales:	Andrew P. Sawaya, Rivka C. Stone, Stephen R. Brooks, Irena Pastar, Ivan Jozic, Kowser Hasneen, Katelyn O’Neill, Spencer Mehdizadeh, Cheyanne R. Head, Natasa Strbo, Maria I. Morasso, Marjana Tomic-Canic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e8acd13f78d4ef9b3a5a1c09f46b7d3
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spelling	oai:doaj.org-article:3e8acd13f78d4ef9b3a5a1c09f46b7d32021-12-02T18:02:32ZDeregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing10.1038/s41467-020-18276-02041-1723https://doaj.org/article/3e8acd13f78d4ef9b3a5a1c09f46b7d32020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18276-0https://doaj.org/toc/2041-1723Diabetic foot ulcers (DFU) represent a complex disease with limited treatment options. Here, the authors compare human RNASeq patient data from DFU, oral mucosa and skin acute wounds, identifying FOXM1 as a mediator of macrophage and neutrophil recruitment, which contributes to disease pathogenesis and is dysregulated in patients.Andrew P. SawayaRivka C. StoneStephen R. BrooksIrena PastarIvan JozicKowser HasneenKatelyn O’NeillSpencer MehdizadehCheyanne R. HeadNatasa StrboMaria I. MorassoMarjana Tomic-CanicNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew P. Sawaya Rivka C. Stone Stephen R. Brooks Irena Pastar Ivan Jozic Kowser Hasneen Katelyn O’Neill Spencer Mehdizadeh Cheyanne R. Head Natasa Strbo Maria I. Morasso Marjana Tomic-Canic Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing
description	Diabetic foot ulcers (DFU) represent a complex disease with limited treatment options. Here, the authors compare human RNASeq patient data from DFU, oral mucosa and skin acute wounds, identifying FOXM1 as a mediator of macrophage and neutrophil recruitment, which contributes to disease pathogenesis and is dysregulated in patients.
format	article
author	Andrew P. Sawaya Rivka C. Stone Stephen R. Brooks Irena Pastar Ivan Jozic Kowser Hasneen Katelyn O’Neill Spencer Mehdizadeh Cheyanne R. Head Natasa Strbo Maria I. Morasso Marjana Tomic-Canic
author_facet	Andrew P. Sawaya Rivka C. Stone Stephen R. Brooks Irena Pastar Ivan Jozic Kowser Hasneen Katelyn O’Neill Spencer Mehdizadeh Cheyanne R. Head Natasa Strbo Maria I. Morasso Marjana Tomic-Canic
author_sort	Andrew P. Sawaya
title	Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing
title_short	Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing
title_full	Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing
title_fullStr	Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing
title_full_unstemmed	Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing
title_sort	deregulated immune cell recruitment orchestrated by foxm1 impairs human diabetic wound healing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3e8acd13f78d4ef9b3a5a1c09f46b7d3
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Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing

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