mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

An increase in glycine decarboxylase (GLDC) activity, a key enzyme for glycine catabolism, has been associated to tumourigenesis. Here, the authors show that mTORC1 activation induces GLDC deacetylation which impairs its ubiquitin-associated degradation leading to increased GLDC activity and tumouri...

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Autores principales:	Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e8e2ec8a90b413e8b695cd802a92e8f
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spelling	oai:doaj.org-article:3e8e2ec8a90b413e8b695cd802a92e8f2021-12-02T16:14:49ZmTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis10.1038/s41467-021-24321-32041-1723https://doaj.org/article/3e8e2ec8a90b413e8b695cd802a92e8f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24321-3https://doaj.org/toc/2041-1723An increase in glycine decarboxylase (GLDC) activity, a key enzyme for glycine catabolism, has been associated to tumourigenesis. Here, the authors show that mTORC1 activation induces GLDC deacetylation which impairs its ubiquitin-associated degradation leading to increased GLDC activity and tumourigenesis.Rui LiuLin-Wen ZengRong GongFanen YuanHong-Bing ShuShu LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rui Liu Lin-Wen Zeng Rong Gong Fanen Yuan Hong-Bing Shu Shu Li mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
description	An increase in glycine decarboxylase (GLDC) activity, a key enzyme for glycine catabolism, has been associated to tumourigenesis. Here, the authors show that mTORC1 activation induces GLDC deacetylation which impairs its ubiquitin-associated degradation leading to increased GLDC activity and tumourigenesis.
format	article
author	Rui Liu Lin-Wen Zeng Rong Gong Fanen Yuan Hong-Bing Shu Shu Li
author_facet	Rui Liu Lin-Wen Zeng Rong Gong Fanen Yuan Hong-Bing Shu Shu Li
author_sort	Rui Liu
title	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
title_short	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
title_full	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
title_fullStr	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
title_full_unstemmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
title_sort	mtorc1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e8e2ec8a90b413e8b695cd802a92e8f
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mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

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