Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.

Many vaccine candidates with promising results in preclinical testing fail in human trials. New complex human tissue models have the potential to improve the predictability of vaccine safety and efficacy in human clinical trials.

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Bibliographic Details
Main Authors:	David Komla Kessie, Thomas Rudel
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2021
Subjects:	Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/3e9a2bb220b045d4ae6e75a8ae2950f2
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spelling	oai:doaj.org-article:3e9a2bb220b045d4ae6e75a8ae2950f22021-12-02T19:54:42ZAdvanced human mucosal tissue models are needed to improve preclinical testing of vaccines.1544-91731545-788510.1371/journal.pbio.3001462https://doaj.org/article/3e9a2bb220b045d4ae6e75a8ae2950f22021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001462https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Many vaccine candidates with promising results in preclinical testing fail in human trials. New complex human tissue models have the potential to improve the predictability of vaccine safety and efficacy in human clinical trials.David Komla KessieThomas RudelPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 11, p e3001462 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 David Komla Kessie Thomas Rudel Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.
description	Many vaccine candidates with promising results in preclinical testing fail in human trials. New complex human tissue models have the potential to improve the predictability of vaccine safety and efficacy in human clinical trials.
format	article
author	David Komla Kessie Thomas Rudel
author_facet	David Komla Kessie Thomas Rudel
author_sort	David Komla Kessie
title	Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.
title_short	Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.
title_full	Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.
title_fullStr	Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.
title_full_unstemmed	Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.
title_sort	advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3e9a2bb220b045d4ae6e75a8ae2950f2
work_keys_str_mv	AT davidkomlakessie advancedhumanmucosaltissuemodelsareneededtoimprovepreclinicaltestingofvaccines AT thomasrudel advancedhumanmucosaltissuemodelsareneededtoimprovepreclinicaltestingofvaccines
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Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines.

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