Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation

Abstract Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated microgravit...

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Autores principales:	Linda Rubinstein, Ann-Sofie Schreurs, Samantha M. Torres, Sonette Steczina, Moniece G. Lowe, Frederico Kiffer, Antiño R. Allen, April E. Ronca, Marianne B. Sowa, Ruth K. Globus, Candice G. T. Tahimic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/3e9da7ae8c2a4834b6f11f00fed4c348
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spelling	oai:doaj.org-article:3e9da7ae8c2a4834b6f11f00fed4c3482021-12-02T15:39:42ZOverexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation10.1038/s41526-021-00152-w2373-8065https://doaj.org/article/3e9da7ae8c2a4834b6f11f00fed4c3482021-07-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00152-whttps://doaj.org/toc/2373-8065Abstract Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated microgravity solely or combined, on the inflammatory cytokine milieu of the hippocampus. Adult female wild-type mice underwent simulated microgravity by hindlimb unloading for 30 days in single or social (paired) housing. In hippocampus, simulated microgravity and isolation each regulate a discrete repertoire of cytokines associated with inflammation. Their combined effects are not additive. A model for mitochondrial reactive oxygen species (ROS) quenching via targeted overexpression of the human catalase gene to the mitochondria (MCAT mice), are protected from isolation- and/or simulated microgravity-induced changes in cytokine expression. These findings suggest a key role for mitochondrial ROS signaling in neuroinflammatory responses to spaceflight and prolonged bedrest, isolation, and confinement on Earth.Linda RubinsteinAnn-Sofie SchreursSamantha M. TorresSonette SteczinaMoniece G. LoweFrederico KifferAntiño R. AllenApril E. RoncaMarianne B. SowaRuth K. GlobusCandice G. T. TahimicNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Linda Rubinstein Ann-Sofie Schreurs Samantha M. Torres Sonette Steczina Moniece G. Lowe Frederico Kiffer Antiño R. Allen April E. Ronca Marianne B. Sowa Ruth K. Globus Candice G. T. Tahimic Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
description	Abstract Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated microgravity solely or combined, on the inflammatory cytokine milieu of the hippocampus. Adult female wild-type mice underwent simulated microgravity by hindlimb unloading for 30 days in single or social (paired) housing. In hippocampus, simulated microgravity and isolation each regulate a discrete repertoire of cytokines associated with inflammation. Their combined effects are not additive. A model for mitochondrial reactive oxygen species (ROS) quenching via targeted overexpression of the human catalase gene to the mitochondria (MCAT mice), are protected from isolation- and/or simulated microgravity-induced changes in cytokine expression. These findings suggest a key role for mitochondrial ROS signaling in neuroinflammatory responses to spaceflight and prolonged bedrest, isolation, and confinement on Earth.
format	article
author	Linda Rubinstein Ann-Sofie Schreurs Samantha M. Torres Sonette Steczina Moniece G. Lowe Frederico Kiffer Antiño R. Allen April E. Ronca Marianne B. Sowa Ruth K. Globus Candice G. T. Tahimic
author_facet	Linda Rubinstein Ann-Sofie Schreurs Samantha M. Torres Sonette Steczina Moniece G. Lowe Frederico Kiffer Antiño R. Allen April E. Ronca Marianne B. Sowa Ruth K. Globus Candice G. T. Tahimic
author_sort	Linda Rubinstein
title	Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
title_short	Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
title_full	Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
title_fullStr	Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
title_full_unstemmed	Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
title_sort	overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e9da7ae8c2a4834b6f11f00fed4c348
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Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation

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