INTERLEUKIN-10 REGULATES PD-1-B7-H1-MEDIATED CYTOTOXIC ACTIVITY OF DENDRITIC CELLS

In this investigation the phenotypic and functional properties of healthy donor and patient with pulmonary tuberculosis (PT) dendritic cells (DCs) were characterized. We also studied the influence of IL-10 on the phenotype and apoptosis-inducing activity of healthy donor DCs. 60 patients with pulmon...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L. V. Sakhno, M. A. Tikhonova, O. Yu. Leplina, A. A. Ostanin, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	b7-h1 il-10 dendritic cells apoptosis Science Q
Acceso en línea:	https://doaj.org/article/3e9f8c7b965e4a8ba2049c947a7bcd87
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3e9f8c7b965e4a8ba2049c947a7bcd87
record_format	dspace
spelling	oai:doaj.org-article:3e9f8c7b965e4a8ba2049c947a7bcd872021-11-23T06:14:19ZINTERLEUKIN-10 REGULATES PD-1-B7-H1-MEDIATED CYTOTOXIC ACTIVITY OF DENDRITIC CELLS2541-94202587-9596https://doaj.org/article/3e9f8c7b965e4a8ba2049c947a7bcd872012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/911https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596In this investigation the phenotypic and functional properties of healthy donor and patient with pulmonary tuberculosis (PT) dendritic cells (DCs) were characterized. We also studied the influence of IL-10 on the phenotype and apoptosis-inducing activity of healthy donor DCs. 60 patients with pulmonary tuberculosis with different proliferative response to antigens of M. tuberculosis (purified protein derivative, PPD) and 40 healthy donors were enrolled in this study. It was revealed that DCs, generated in vitro from PT patient's blood monocytes with GM-CSF+IFN-α, were characterized by increased B7-H1 expression, up-production of IL-10 and reducing of allostimulatory activity in mixed lymphocyte culture (MLC). The endogenous IL-10 production by DCs was correlated with expression of B7-H1 in the general group of persons. It was revealed that addition of IL-10 to semi-mature DCs of healthy donor results in increasing of B7-H1 expression, diminishing of allostimulatory activity and enlargement of pro-apoptogenic activity of DCs.L. V. SakhnoM. A. TikhonovaO. Yu. LeplinaA. A. OstaninE. R. ChernykhScientific Сentre for Family Health and Human Reproduction Problemsarticleb7-h1il-10b7-h1dendritic cellsapoptosisil-10ScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 170-174 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	b7-h1 il-10 b7-h1 dendritic cells apoptosis il-10 Science Q
spellingShingle	b7-h1 il-10 b7-h1 dendritic cells apoptosis il-10 Science Q L. V. Sakhno M. A. Tikhonova O. Yu. Leplina A. A. Ostanin E. R. Chernykh INTERLEUKIN-10 REGULATES PD-1-B7-H1-MEDIATED CYTOTOXIC ACTIVITY OF DENDRITIC CELLS
description	In this investigation the phenotypic and functional properties of healthy donor and patient with pulmonary tuberculosis (PT) dendritic cells (DCs) were characterized. We also studied the influence of IL-10 on the phenotype and apoptosis-inducing activity of healthy donor DCs. 60 patients with pulmonary tuberculosis with different proliferative response to antigens of M. tuberculosis (purified protein derivative, PPD) and 40 healthy donors were enrolled in this study. It was revealed that DCs, generated in vitro from PT patient's blood monocytes with GM-CSF+IFN-α, were characterized by increased B7-H1 expression, up-production of IL-10 and reducing of allostimulatory activity in mixed lymphocyte culture (MLC). The endogenous IL-10 production by DCs was correlated with expression of B7-H1 in the general group of persons. It was revealed that addition of IL-10 to semi-mature DCs of healthy donor results in increasing of B7-H1 expression, diminishing of allostimulatory activity and enlargement of pro-apoptogenic activity of DCs.
format	article
author	L. V. Sakhno M. A. Tikhonova O. Yu. Leplina A. A. Ostanin E. R. Chernykh
author_facet	L. V. Sakhno M. A. Tikhonova O. Yu. Leplina A. A. Ostanin E. R. Chernykh
author_sort	L. V. Sakhno
title	INTERLEUKIN-10 REGULATES PD-1-B7-H1-MEDIATED CYTOTOXIC ACTIVITY OF DENDRITIC CELLS
title_short	INTERLEUKIN-10 REGULATES PD-1-B7-H1-MEDIATED CYTOTOXIC ACTIVITY OF DENDRITIC CELLS
title_full	INTERLEUKIN-10 REGULATES PD-1-B7-H1-MEDIATED CYTOTOXIC ACTIVITY OF DENDRITIC CELLS
title_fullStr	INTERLEUKIN-10 REGULATES PD-1-B7-H1-MEDIATED CYTOTOXIC ACTIVITY OF DENDRITIC CELLS
title_full_unstemmed	INTERLEUKIN-10 REGULATES PD-1-B7-H1-MEDIATED CYTOTOXIC ACTIVITY OF DENDRITIC CELLS
title_sort	interleukin-10 regulates pd-1-b7-h1-mediated cytotoxic activity of dendritic cells
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/3e9f8c7b965e4a8ba2049c947a7bcd87
work_keys_str_mv	AT lvsakhno interleukin10regulatespd1b7h1mediatedcytotoxicactivityofdendriticcells AT matikhonova interleukin10regulatespd1b7h1mediatedcytotoxicactivityofdendriticcells AT oyuleplina interleukin10regulatespd1b7h1mediatedcytotoxicactivityofdendriticcells AT aaostanin interleukin10regulatespd1b7h1mediatedcytotoxicactivityofdendriticcells AT erchernykh interleukin10regulatespd1b7h1mediatedcytotoxicactivityofdendriticcells
_version_	1718417313255915520

INTERLEUKIN-10 REGULATES PD-1-B7-H1-MEDIATED CYTOTOXIC ACTIVITY OF DENDRITIC CELLS

Ejemplares similares