Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study

Abstract We investigated the clinical relevance of urinary cytokines/chemokines reflecting intrarenal immunologic micromilieu as prognostic markers and the optimal measurement timing after living donor kidney transplantation (LDKT). This prospective cohort study included 77 LDKT patients who were fo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hye Ryoun Jang, Minjung Kim, Sungjun Hong, Kyungho Lee, Mee Yeon Park, Kyeong Eun Yang, Cheol-Jung Lee, Junseok Jeon, Kyo Won Lee, Jung Eun Lee, Jae Berm Park, Kyunga Kim, Ghee Young Kwon, Yoon Goo Kim, Dae Joong Kim, Wooseong Huh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ea217acd66c4c8082e1eeef0d3f4a89
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3ea217acd66c4c8082e1eeef0d3f4a89
record_format	dspace
spelling	oai:doaj.org-article:3ea217acd66c4c8082e1eeef0d3f4a892021-12-02T15:15:23ZEarly postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study10.1038/s41598-021-98135-02045-2322https://doaj.org/article/3ea217acd66c4c8082e1eeef0d3f4a892021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98135-0https://doaj.org/toc/2045-2322Abstract We investigated the clinical relevance of urinary cytokines/chemokines reflecting intrarenal immunologic micromilieu as prognostic markers and the optimal measurement timing after living donor kidney transplantation (LDKT). This prospective cohort study included 77 LDKT patients who were followed for ≥ 5 years. Patients were divided into control (n = 42) or acute rejection (AR, n = 35) group. Early AR was defined as AR occurring within 3 months. Serum and urine cytokines/chemokines were measured serially as follows: intraoperative, 8/24/72 h, 1 week, 3 months, and 1 year after LDKT. Intrarenal total leukocytes, T cells, and B cells were analyzed with immunohistochemistry followed by tissueFAXS. Urinary MCP-1 and fractalkine were also analyzed in a validation cohort. Urinary MCP-1 after one week was higher in the AR group. Urinary MCP-1, fractalkine, TNF-α, RANTES, and IL-6 after one week were significantly higher in the early AR group. Intrarenal total leukocytes and T cells were elevated in the AR group compared with the control group. Urinary fractalkine, MCP-1, and IL-10 showed positive correlation with intrarenal leukocyte infiltration. Post-KT 1 week urinary MCP-1 showed predictive value in the validation cohort. One-week post-KT urinary MCP-1 may be used as a noninvasive diagnostic marker for predicting AR after LDKT.Hye Ryoun JangMinjung KimSungjun HongKyungho LeeMee Yeon ParkKyeong Eun YangCheol-Jung LeeJunseok JeonKyo Won LeeJung Eun LeeJae Berm ParkKyunga KimGhee Young KwonYoon Goo KimDae Joong KimWooseong HuhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye Ryoun Jang Minjung Kim Sungjun Hong Kyungho Lee Mee Yeon Park Kyeong Eun Yang Cheol-Jung Lee Junseok Jeon Kyo Won Lee Jung Eun Lee Jae Berm Park Kyunga Kim Ghee Young Kwon Yoon Goo Kim Dae Joong Kim Wooseong Huh Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study
description	Abstract We investigated the clinical relevance of urinary cytokines/chemokines reflecting intrarenal immunologic micromilieu as prognostic markers and the optimal measurement timing after living donor kidney transplantation (LDKT). This prospective cohort study included 77 LDKT patients who were followed for ≥ 5 years. Patients were divided into control (n = 42) or acute rejection (AR, n = 35) group. Early AR was defined as AR occurring within 3 months. Serum and urine cytokines/chemokines were measured serially as follows: intraoperative, 8/24/72 h, 1 week, 3 months, and 1 year after LDKT. Intrarenal total leukocytes, T cells, and B cells were analyzed with immunohistochemistry followed by tissueFAXS. Urinary MCP-1 and fractalkine were also analyzed in a validation cohort. Urinary MCP-1 after one week was higher in the AR group. Urinary MCP-1, fractalkine, TNF-α, RANTES, and IL-6 after one week were significantly higher in the early AR group. Intrarenal total leukocytes and T cells were elevated in the AR group compared with the control group. Urinary fractalkine, MCP-1, and IL-10 showed positive correlation with intrarenal leukocyte infiltration. Post-KT 1 week urinary MCP-1 showed predictive value in the validation cohort. One-week post-KT urinary MCP-1 may be used as a noninvasive diagnostic marker for predicting AR after LDKT.
format	article
author	Hye Ryoun Jang Minjung Kim Sungjun Hong Kyungho Lee Mee Yeon Park Kyeong Eun Yang Cheol-Jung Lee Junseok Jeon Kyo Won Lee Jung Eun Lee Jae Berm Park Kyunga Kim Ghee Young Kwon Yoon Goo Kim Dae Joong Kim Wooseong Huh
author_facet	Hye Ryoun Jang Minjung Kim Sungjun Hong Kyungho Lee Mee Yeon Park Kyeong Eun Yang Cheol-Jung Lee Junseok Jeon Kyo Won Lee Jung Eun Lee Jae Berm Park Kyunga Kim Ghee Young Kwon Yoon Goo Kim Dae Joong Kim Wooseong Huh
author_sort	Hye Ryoun Jang
title	Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study
title_short	Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study
title_full	Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study
title_fullStr	Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study
title_full_unstemmed	Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study
title_sort	early postoperative urinary mcp-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ea217acd66c4c8082e1eeef0d3f4a89
work_keys_str_mv	AT hyeryounjang earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT minjungkim earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT sungjunhong earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT kyungholee earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT meeyeonpark earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT kyeongeunyang earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT cheoljunglee earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT junseokjeon earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT kyowonlee earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT jungeunlee earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT jaebermpark earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT kyungakim earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT gheeyoungkwon earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT yoongookim earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT daejoongkim earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy AT wooseonghuh earlypostoperativeurinarymcp1asapotentialbiomarkerpredictingacuterejectioninlivingdonorkidneytransplantationaprospectivecohortstudy
_version_	1718387500981944320

Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study

Ejemplares similares