Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery

Abstract Bariatric and metabolic surgery has shown to promote weight loss and reduce systemic inflammation. However, the sequence and timing of events regarding metabolic improvement and inflammation resolution has been rarely explored. Furthermore, data on inflammatory markers of Th17 and Th1 cell...

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Autores principales:	Jose Romeo Villarreal-Calderon, Ricardo Cuellar-Tamez, Elena C. Castillo, Eder Luna-Ceron, Gerardo García-Rivas, Leticia Elizondo-Montemayor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ea6c9741d4a4a93b371e624f256d546
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spelling	oai:doaj.org-article:3ea6c9741d4a4a93b371e624f256d5462021-12-02T17:47:37ZMetabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery10.1038/s41598-021-91393-y2045-2322https://doaj.org/article/3ea6c9741d4a4a93b371e624f256d5462021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91393-yhttps://doaj.org/toc/2045-2322Abstract Bariatric and metabolic surgery has shown to promote weight loss and reduce systemic inflammation. However, the sequence and timing of events regarding metabolic improvement and inflammation resolution has been rarely explored. Furthermore, data on inflammatory markers of Th17 and Th1 cell responses after bariatric surgery is scarce. We conducted a prospective study in subjects with obesity that underwent bariatric and metabolic surgery, with follow-ups at 3 and 6 months. Anthropometric and metabolic markers such as insulin levels, HOMA-IR, and lipid parameters declined significantly 3 months after surgery; while hs-CRP, TNF-α, IL-1β, IL-6, and IL-8 serum concentrations decreased 6 months after the procedure. Concentrations of Th1 signature and driver cytokines, particularly IFN-γ, IL-12, and IL-18, and of Th17 driver IL-23 also decreased significantly after 6 months. Significant positive correlations between triglyceride levels and hs-CRP, IL-1β, and IFN-γ concentrations, and between Apo B and IFN-γ levels were observed 6 months after bariatric and metabolic surgery. In addition, BMI was associated with hs-CRP and TNF-α concentrations. Fat mass correlated with hs-CRP, TNF-α, and IL-12. Analysis of the temporality of metabolic and inflammatory events suggests that improvement in the metabolic status occurs before resolution of systemic inflammation and may be a requisite for the later event.Jose Romeo Villarreal-CalderonRicardo Cuellar-TamezElena C. CastilloEder Luna-CeronGerardo García-RivasLeticia Elizondo-MontemayorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jose Romeo Villarreal-Calderon Ricardo Cuellar-Tamez Elena C. Castillo Eder Luna-Ceron Gerardo García-Rivas Leticia Elizondo-Montemayor Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery
description	Abstract Bariatric and metabolic surgery has shown to promote weight loss and reduce systemic inflammation. However, the sequence and timing of events regarding metabolic improvement and inflammation resolution has been rarely explored. Furthermore, data on inflammatory markers of Th17 and Th1 cell responses after bariatric surgery is scarce. We conducted a prospective study in subjects with obesity that underwent bariatric and metabolic surgery, with follow-ups at 3 and 6 months. Anthropometric and metabolic markers such as insulin levels, HOMA-IR, and lipid parameters declined significantly 3 months after surgery; while hs-CRP, TNF-α, IL-1β, IL-6, and IL-8 serum concentrations decreased 6 months after the procedure. Concentrations of Th1 signature and driver cytokines, particularly IFN-γ, IL-12, and IL-18, and of Th17 driver IL-23 also decreased significantly after 6 months. Significant positive correlations between triglyceride levels and hs-CRP, IL-1β, and IFN-γ concentrations, and between Apo B and IFN-γ levels were observed 6 months after bariatric and metabolic surgery. In addition, BMI was associated with hs-CRP and TNF-α concentrations. Fat mass correlated with hs-CRP, TNF-α, and IL-12. Analysis of the temporality of metabolic and inflammatory events suggests that improvement in the metabolic status occurs before resolution of systemic inflammation and may be a requisite for the later event.
format	article
author	Jose Romeo Villarreal-Calderon Ricardo Cuellar-Tamez Elena C. Castillo Eder Luna-Ceron Gerardo García-Rivas Leticia Elizondo-Montemayor
author_facet	Jose Romeo Villarreal-Calderon Ricardo Cuellar-Tamez Elena C. Castillo Eder Luna-Ceron Gerardo García-Rivas Leticia Elizondo-Montemayor
author_sort	Jose Romeo Villarreal-Calderon
title	Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery
title_short	Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery
title_full	Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery
title_fullStr	Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery
title_full_unstemmed	Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery
title_sort	metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ea6c9741d4a4a93b371e624f256d546
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Metabolic shift precedes the resolution of inflammation in a cohort of patients undergoing bariatric and metabolic surgery

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