A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy

Abstract The aim of this study was to evaluate the effects of deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) on systemic inflammatory responses in patients with drug-resistant epilepsy (DRE). Twenty-two Finnish patients with ANT-DBS implantation were enrolled in this pilot...

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Autores principales:	Pabitra Basnyat, Soila Järvenpää, Jani Raitanen, Marko Pesu, Kai Lehtimäki, Jukka Peltola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3eb092a38bce42ac804b62bfdb577a75
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spelling	oai:doaj.org-article:3eb092a38bce42ac804b62bfdb577a752021-12-02T16:10:24ZA 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy10.1038/s41598-021-93265-x2045-2322https://doaj.org/article/3eb092a38bce42ac804b62bfdb577a752021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93265-xhttps://doaj.org/toc/2045-2322Abstract The aim of this study was to evaluate the effects of deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) on systemic inflammatory responses in patients with drug-resistant epilepsy (DRE). Twenty-two Finnish patients with ANT-DBS implantation were enrolled in this pilot study. Changes in plasma interleukin-6 (IL-6) and interleukin-10 (IL-10) levels were examined using generalized estimating equation models at seven time points (before DBS surgery and 1, 2, 3, 6, 9 and 12 months after implantation). In the whole group, the IL-6/IL-10 ratio decreased significantly over time following ANT-DBS, while the decrease in IL-6 levels and increase in IL-10 levels were not significant. In the responder and nonresponder groups, IL-6 levels remained unchanged during the follow-up. Responders had significantly lower pre-DBS IL-10 levels before the ANT-DBS treatment than nonresponders, but the levels significantly increased over time after the treatment. In addition, responders had a higher pre-DBS IL-6/IL-10 ratio than nonresponders, and the ratio decreased for both groups after treatment, but the decrease did not reach the level of statistical significance. The rate of decrease in the ratio per month tended to be higher in responders than in nonresponders. These results may highlight the anti-inflammatory properties of ANT-DBS treatment associated with its therapeutic effectiveness in patients with DRE. Additional studies are essential to evaluate the potential of the proinflammatory cytokine IL-6, the anti-inflammatory cytokine IL-10, and their ratio as biomarkers to evaluate the therapeutic response to DBS treatment, which could facilitate treatment optimization.Pabitra BasnyatSoila JärvenpääJani RaitanenMarko PesuKai LehtimäkiJukka PeltolaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pabitra Basnyat Soila Järvenpää Jani Raitanen Marko Pesu Kai Lehtimäki Jukka Peltola A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy
description	Abstract The aim of this study was to evaluate the effects of deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) on systemic inflammatory responses in patients with drug-resistant epilepsy (DRE). Twenty-two Finnish patients with ANT-DBS implantation were enrolled in this pilot study. Changes in plasma interleukin-6 (IL-6) and interleukin-10 (IL-10) levels were examined using generalized estimating equation models at seven time points (before DBS surgery and 1, 2, 3, 6, 9 and 12 months after implantation). In the whole group, the IL-6/IL-10 ratio decreased significantly over time following ANT-DBS, while the decrease in IL-6 levels and increase in IL-10 levels were not significant. In the responder and nonresponder groups, IL-6 levels remained unchanged during the follow-up. Responders had significantly lower pre-DBS IL-10 levels before the ANT-DBS treatment than nonresponders, but the levels significantly increased over time after the treatment. In addition, responders had a higher pre-DBS IL-6/IL-10 ratio than nonresponders, and the ratio decreased for both groups after treatment, but the decrease did not reach the level of statistical significance. The rate of decrease in the ratio per month tended to be higher in responders than in nonresponders. These results may highlight the anti-inflammatory properties of ANT-DBS treatment associated with its therapeutic effectiveness in patients with DRE. Additional studies are essential to evaluate the potential of the proinflammatory cytokine IL-6, the anti-inflammatory cytokine IL-10, and their ratio as biomarkers to evaluate the therapeutic response to DBS treatment, which could facilitate treatment optimization.
format	article
author	Pabitra Basnyat Soila Järvenpää Jani Raitanen Marko Pesu Kai Lehtimäki Jukka Peltola
author_facet	Pabitra Basnyat Soila Järvenpää Jani Raitanen Marko Pesu Kai Lehtimäki Jukka Peltola
author_sort	Pabitra Basnyat
title	A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy
title_short	A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy
title_full	A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy
title_fullStr	A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy
title_full_unstemmed	A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy
title_sort	1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3eb092a38bce42ac804b62bfdb577a75
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A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy

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