The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model
Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent bactericidal activity against Mycobacterium ulcerans in vitro and in a mouse model, which underscores its potential for shortening the course of BU and treating other mycobacterial...
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Nature Portfolio
2019
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oai:doaj.org-article:3eb099eeaf12439699ea5255f9ccaab62021-12-02T17:01:45ZThe compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model10.1038/s41467-019-08464-y2041-1723https://doaj.org/article/3eb099eeaf12439699ea5255f9ccaab62019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08464-yhttps://doaj.org/toc/2041-1723Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent bactericidal activity against Mycobacterium ulcerans in vitro and in a mouse model, which underscores its potential for shortening the course of BU and treating other mycobacterial diseases.Yang LiuYamin GaoJianxiong LiuYaoju TanZhiyong LiuChiranjibi ChhotarayHuofeng JiangZhili LuGift ChiwalaShuai WangGaelle MakafeMd Mahmudul IslamH. M. Adnan HameedXingshan CaiChangwei WangXinjie LiShouyong TanTianyu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019) |
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Science Q |
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Science Q Yang Liu Yamin Gao Jianxiong Liu Yaoju Tan Zhiyong Liu Chiranjibi Chhotaray Huofeng Jiang Zhili Lu Gift Chiwala Shuai Wang Gaelle Makafe Md Mahmudul Islam H. M. Adnan Hameed Xingshan Cai Changwei Wang Xinjie Li Shouyong Tan Tianyu Zhang The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| description |
Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent bactericidal activity against Mycobacterium ulcerans in vitro and in a mouse model, which underscores its potential for shortening the course of BU and treating other mycobacterial diseases. |
| format |
article |
| author |
Yang Liu Yamin Gao Jianxiong Liu Yaoju Tan Zhiyong Liu Chiranjibi Chhotaray Huofeng Jiang Zhili Lu Gift Chiwala Shuai Wang Gaelle Makafe Md Mahmudul Islam H. M. Adnan Hameed Xingshan Cai Changwei Wang Xinjie Li Shouyong Tan Tianyu Zhang |
| author_facet |
Yang Liu Yamin Gao Jianxiong Liu Yaoju Tan Zhiyong Liu Chiranjibi Chhotaray Huofeng Jiang Zhili Lu Gift Chiwala Shuai Wang Gaelle Makafe Md Mahmudul Islam H. M. Adnan Hameed Xingshan Cai Changwei Wang Xinjie Li Shouyong Tan Tianyu Zhang |
| author_sort |
Yang Liu |
| title |
The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_short |
The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_full |
The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_fullStr |
The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_full_unstemmed |
The compound TB47 is highly bactericidal against Mycobacterium ulcerans in a Buruli ulcer mouse model |
| title_sort |
compound tb47 is highly bactericidal against mycobacterium ulcerans in a buruli ulcer mouse model |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/3eb099eeaf12439699ea5255f9ccaab6 |
| work_keys_str_mv |
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