Protein context shapes the specificity of SH3 domain-mediated interactions in vivo

Protein context shapes the specificity of SH3 domain-mediated interactions in vivo

The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specificity and thus the PPI-dependent cellular functions.

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Detalles Bibliográficos
Autores principales: Ugo Dionne, Émilie Bourgault, Alexandre K. Dubé, David Bradley, François J. M. Chartier, Rohan Dandage, Soham Dibyachintan, Philippe C. Després, Gerald D. Gish, N. T. Hang Pham, Myriam Létourneau, Jean-Philippe Lambert, Nicolas Doucet, Nicolas Bisson, Christian R. Landry
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
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Sumario:The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specificity and thus the PPI-dependent cellular functions.

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