Protein context shapes the specificity of SH3 domain-mediated interactions in vivo

The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specificity and thus the PPI-dependent cellular functions.

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Autores principales:	Ugo Dionne, Émilie Bourgault, Alexandre K. Dubé, David Bradley, François J. M. Chartier, Rohan Dandage, Soham Dibyachintan, Philippe C. Després, Gerald D. Gish, N. T. Hang Pham, Myriam Létourneau, Jean-Philippe Lambert, Nicolas Doucet, Nicolas Bisson, Christian R. Landry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
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spelling	oai:doaj.org-article:3eb0d24dbb7e42d98c601ea7d75ada6a2021-12-02T15:52:28ZProtein context shapes the specificity of SH3 domain-mediated interactions in vivo10.1038/s41467-021-21873-22041-1723https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21873-2https://doaj.org/toc/2041-1723The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specificity and thus the PPI-dependent cellular functions.Ugo DionneÉmilie BourgaultAlexandre K. DubéDavid BradleyFrançois J. M. ChartierRohan DandageSoham DibyachintanPhilippe C. DesprésGerald D. GishN. T. Hang PhamMyriam LétourneauJean-Philippe LambertNicolas DoucetNicolas BissonChristian R. LandryNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ugo Dionne Émilie Bourgault Alexandre K. Dubé David Bradley François J. M. Chartier Rohan Dandage Soham Dibyachintan Philippe C. Després Gerald D. Gish N. T. Hang Pham Myriam Létourneau Jean-Philippe Lambert Nicolas Doucet Nicolas Bisson Christian R. Landry Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
description	The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specificity and thus the PPI-dependent cellular functions.
format	article
author	Ugo Dionne Émilie Bourgault Alexandre K. Dubé David Bradley François J. M. Chartier Rohan Dandage Soham Dibyachintan Philippe C. Després Gerald D. Gish N. T. Hang Pham Myriam Létourneau Jean-Philippe Lambert Nicolas Doucet Nicolas Bisson Christian R. Landry
author_facet	Ugo Dionne Émilie Bourgault Alexandre K. Dubé David Bradley François J. M. Chartier Rohan Dandage Soham Dibyachintan Philippe C. Després Gerald D. Gish N. T. Hang Pham Myriam Létourneau Jean-Philippe Lambert Nicolas Doucet Nicolas Bisson Christian R. Landry
author_sort	Ugo Dionne
title	Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
title_short	Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
title_full	Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
title_fullStr	Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
title_full_unstemmed	Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
title_sort	protein context shapes the specificity of sh3 domain-mediated interactions in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
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Protein context shapes the specificity of SH3 domain-mediated interactions in vivo

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