GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent

Abstract. Nurcholis W, Khumaida N, Bintang M, Syukur M. 2021. GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent. Biodiversitas 22: 1179-1186. This work aimed to evaluate the bioactive compounds and anticancer activity in...

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Autores principales:	Waras Nurcholis, NURUL KHUMAIDA, MARIA BINTANG, MUHAMAD SYUKUR
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2021
Materias:	agricultural biochemistry, bioactivities, chemometric analysis, profiling metabolite, volatile compounds Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3eb11594779a4ea393fdb61f2bdf57c1
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spelling	oai:doaj.org-article:3eb11594779a4ea393fdb61f2bdf57c12021-11-22T00:56:37ZGC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent1412-033X2085-472210.13057/biodiv/d220313https://doaj.org/article/3eb11594779a4ea393fdb61f2bdf57c12021-02-01T00:00:00Zhttps://smujo.id/biodiv/article/view/7900https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Nurcholis W, Khumaida N, Bintang M, Syukur M. 2021. GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent. Biodiversitas 22: 1179-1186. This work aimed to evaluate the bioactive compounds and anticancer activity in rhizome extract of ten Curcuma aeruginosa accessions to explore their pharmacological values. The GC-MS analysis was used to identify bioactive compounds. The cytotoxic activity was performed against MCF-7 (Human breastadeno carcinoma) and Vero cell lines using MTT assay. The GC-MS analysis revealed 71 of the compounds as sesquiterpenes (36), monoterpenes (20), phenolics (5), diterpenes (4), phenanthrene (1), tetrapeptides (1), oxazole (1), triazine (1), piperidine (1), and oxygenated hydrocarbons (1). The isocurcumenol was the most dominant metabolite in ethanol extract of C. aeruginosa rhizome, with the highest produced by KP accession (22.01%) followed MD accession (21.12%). However, camphor and ?-elemene were the metabolites produced by all accessions studied. In the Vero cell line as a normal cell, the cytotoxic activity varied from 13.28% (MD) to 45.17% (PW). Furthermore, the cytotoxic activity ranged from 1.16% (LC) to 49.70% (MD) against the MCF-7 cell line. The highest anticancer activity was produced in MD accessions; thus, it can be used as a source of quality raw materials for the pharmaceutical and food industry. Besides that, it can also be further developed to obtain superior varieties through plant breeding programs.Waras NurcholisNURUL KHUMAIDAMARIA BINTANGMUHAMAD SYUKURMBI & UNS Soloarticleagricultural biochemistry, bioactivities, chemometric analysis, profiling metabolite, volatile compoundsBiology (General)QH301-705.5ENBiodiversitas, Vol 22, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	agricultural biochemistry, bioactivities, chemometric analysis, profiling metabolite, volatile compounds Biology (General) QH301-705.5
spellingShingle	agricultural biochemistry, bioactivities, chemometric analysis, profiling metabolite, volatile compounds Biology (General) QH301-705.5 Waras Nurcholis NURUL KHUMAIDA MARIA BINTANG MUHAMAD SYUKUR GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent
description	Abstract. Nurcholis W, Khumaida N, Bintang M, Syukur M. 2021. GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent. Biodiversitas 22: 1179-1186. This work aimed to evaluate the bioactive compounds and anticancer activity in rhizome extract of ten Curcuma aeruginosa accessions to explore their pharmacological values. The GC-MS analysis was used to identify bioactive compounds. The cytotoxic activity was performed against MCF-7 (Human breastadeno carcinoma) and Vero cell lines using MTT assay. The GC-MS analysis revealed 71 of the compounds as sesquiterpenes (36), monoterpenes (20), phenolics (5), diterpenes (4), phenanthrene (1), tetrapeptides (1), oxazole (1), triazine (1), piperidine (1), and oxygenated hydrocarbons (1). The isocurcumenol was the most dominant metabolite in ethanol extract of C. aeruginosa rhizome, with the highest produced by KP accession (22.01%) followed MD accession (21.12%). However, camphor and ?-elemene were the metabolites produced by all accessions studied. In the Vero cell line as a normal cell, the cytotoxic activity varied from 13.28% (MD) to 45.17% (PW). Furthermore, the cytotoxic activity ranged from 1.16% (LC) to 49.70% (MD) against the MCF-7 cell line. The highest anticancer activity was produced in MD accessions; thus, it can be used as a source of quality raw materials for the pharmaceutical and food industry. Besides that, it can also be further developed to obtain superior varieties through plant breeding programs.
format	article
author	Waras Nurcholis NURUL KHUMAIDA MARIA BINTANG MUHAMAD SYUKUR
author_facet	Waras Nurcholis NURUL KHUMAIDA MARIA BINTANG MUHAMAD SYUKUR
author_sort	Waras Nurcholis
title	GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent
title_short	GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent
title_full	GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent
title_fullStr	GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent
title_full_unstemmed	GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent
title_sort	gc-ms analysis of rhizome ethanol extracts from curcuma aeruginosa accessions and their efficiency activities as anticancer agent
publisher	MBI & UNS Solo
publishDate	2021
url	https://doaj.org/article/3eb11594779a4ea393fdb61f2bdf57c1
work_keys_str_mv	AT warasnurcholis gcmsanalysisofrhizomeethanolextractsfromcurcumaaeruginosaaccessionsandtheirefficiencyactivitiesasanticanceragent AT nurulkhumaida gcmsanalysisofrhizomeethanolextractsfromcurcumaaeruginosaaccessionsandtheirefficiencyactivitiesasanticanceragent AT mariabintang gcmsanalysisofrhizomeethanolextractsfromcurcumaaeruginosaaccessionsandtheirefficiencyactivitiesasanticanceragent AT muhamadsyukur gcmsanalysisofrhizomeethanolextractsfromcurcumaaeruginosaaccessionsandtheirefficiencyactivitiesasanticanceragent
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GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent

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