RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix

It is unclear what regulates the fate of mesenchymal stem cells (MSCs) in arterial repair following injury. Here, the authors show that MSC differentiation following injury is triggered by RhoA which in turn stimulates the release of connective tissue growth factor and vascular endothelial growth fa...

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Autores principales:	Changjun Li, Gehua Zhen, Yu Chai, Liang Xie, Janet L. Crane, Emily Farber, Charles R. Farber, Xianghang Luo, Peisong Gao, Xu Cao, Mei Wan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3eb49847a740494ba08e8723147d5be3
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spelling	oai:doaj.org-article:3eb49847a740494ba08e8723147d5be32021-12-02T15:33:49ZRhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix10.1038/ncomms114552041-1723https://doaj.org/article/3eb49847a740494ba08e8723147d5be32016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11455https://doaj.org/toc/2041-1723It is unclear what regulates the fate of mesenchymal stem cells (MSCs) in arterial repair following injury. Here, the authors show that MSC differentiation following injury is triggered by RhoA which in turn stimulates the release of connective tissue growth factor and vascular endothelial growth factor.Changjun LiGehua ZhenYu ChaiLiang XieJanet L. CraneEmily FarberCharles R. FarberXianghang LuoPeisong GaoXu CaoMei WanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Changjun Li Gehua Zhen Yu Chai Liang Xie Janet L. Crane Emily Farber Charles R. Farber Xianghang Luo Peisong Gao Xu Cao Mei Wan RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
description	It is unclear what regulates the fate of mesenchymal stem cells (MSCs) in arterial repair following injury. Here, the authors show that MSC differentiation following injury is triggered by RhoA which in turn stimulates the release of connective tissue growth factor and vascular endothelial growth factor.
format	article
author	Changjun Li Gehua Zhen Yu Chai Liang Xie Janet L. Crane Emily Farber Charles R. Farber Xianghang Luo Peisong Gao Xu Cao Mei Wan
author_facet	Changjun Li Gehua Zhen Yu Chai Liang Xie Janet L. Crane Emily Farber Charles R. Farber Xianghang Luo Peisong Gao Xu Cao Mei Wan
author_sort	Changjun Li
title	RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_short	RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_full	RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_fullStr	RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_full_unstemmed	RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_sort	rhoa determines lineage fate of mesenchymal stem cells by modulating ctgf–vegf complex in extracellular matrix
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3eb49847a740494ba08e8723147d5be3
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RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix

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