Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis
(1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platele...
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3eb4d942ea7440a685682290729495be |
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| Sumario: | (1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platelet count, homocysteine. (2) Methods: We studied 337 patients with IE. Clinical, hemato-chemical and echocardiography parameters were analyzed. Coagulation parameters were measured on admission. (3) Results: D-dimers levels (<i>p</i> = 0.012) and a prolonged PT-INR (<i>p</i> = 0.013) were associated with higher in-hospital mortality, while prolonged aPTT (<i>p</i> = 0.021) was associated with increased 1-year mortality. <i>Staphylococcus aureus</i> (<i>S. aureus</i>) infection (<i>p</i> = 0.003), prosthetic valve endocarditis (PVE) (<i>p</i> = 0.001), surgical indication (<i>p</i> = 0.002) and higher D-dimer levels (<i>p</i> = 0.005) were independent predictors of in-hospital mortality. PVE (<i>p</i> = 0.001), a higher Charlson Comorbidity Index (<i>p</i> = 0.049), surgical indication (<i>p</i> = 0.001) and prolonged aPTT (<i>p</i> = 0.012) were independent predictors of 1-year mortality. Higher levels of D-dimers (<i>p</i> < 0.001) and a shorter aPTT (<i>p</i> < 0.001) were associated with embolic complications of IE. <i>S. aureus</i> etiology was bound to higher D-dimers levels (<i>p</i> < 0.001) and a shorter aPTT (<i>p</i> = 0.006). (4) Conclusions: Elevated D-dimers are associated with a higher risk for in-hospital mortality in IE patients. High D-dimers and a short aPTT are associated with a higher risk for embolic events in IE. A longer aPTT is associated with 1-year mortality. |
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