Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Direct visualization of microglia-mediated synapse pruning has been lacking. This study shows direct evidence of microglia-synapse interaction where microglia do not necessarily ‘eat’ post-synaptic structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.

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Autores principales:	Laetitia Weinhard, Giulia di Bartolomei, Giulia Bolasco, Pedro Machado, Nicole L. Schieber, Urte Neniskyte, Melanie Exiga, Auguste Vadisiute, Angelo Raggioli, Andreas Schertel, Yannick Schwab, Cornelius T. Gross
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ebaa88953d7458785bcccb29c6b1bc7
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spelling	oai:doaj.org-article:3ebaa88953d7458785bcccb29c6b1bc72021-12-02T14:41:16ZMicroglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction10.1038/s41467-018-03566-52041-1723https://doaj.org/article/3ebaa88953d7458785bcccb29c6b1bc72018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03566-5https://doaj.org/toc/2041-1723Direct visualization of microglia-mediated synapse pruning has been lacking. This study shows direct evidence of microglia-synapse interaction where microglia do not necessarily ‘eat’ post-synaptic structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.Laetitia WeinhardGiulia di BartolomeiGiulia BolascoPedro MachadoNicole L. SchieberUrte NeniskyteMelanie ExigaAuguste VadisiuteAngelo RaggioliAndreas SchertelYannick SchwabCornelius T. GrossNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laetitia Weinhard Giulia di Bartolomei Giulia Bolasco Pedro Machado Nicole L. Schieber Urte Neniskyte Melanie Exiga Auguste Vadisiute Angelo Raggioli Andreas Schertel Yannick Schwab Cornelius T. Gross Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
description	Direct visualization of microglia-mediated synapse pruning has been lacking. This study shows direct evidence of microglia-synapse interaction where microglia do not necessarily ‘eat’ post-synaptic structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.
format	article
author	Laetitia Weinhard Giulia di Bartolomei Giulia Bolasco Pedro Machado Nicole L. Schieber Urte Neniskyte Melanie Exiga Auguste Vadisiute Angelo Raggioli Andreas Schertel Yannick Schwab Cornelius T. Gross
author_facet	Laetitia Weinhard Giulia di Bartolomei Giulia Bolasco Pedro Machado Nicole L. Schieber Urte Neniskyte Melanie Exiga Auguste Vadisiute Angelo Raggioli Andreas Schertel Yannick Schwab Cornelius T. Gross
author_sort	Laetitia Weinhard
title	Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_short	Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_full	Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_fullStr	Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_full_unstemmed	Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_sort	microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3ebaa88953d7458785bcccb29c6b1bc7
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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

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