Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Direct visualization of microglia-mediated synapse pruning has been lacking. This study shows direct evidence of microglia-synapse interaction where microglia do not necessarily ‘eat’ post-synaptic structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.
Guardado en:
Autores principales: | Laetitia Weinhard, Giulia di Bartolomei, Giulia Bolasco, Pedro Machado, Nicole L. Schieber, Urte Neniskyte, Melanie Exiga, Auguste Vadisiute, Angelo Raggioli, Andreas Schertel, Yannick Schwab, Cornelius T. Gross |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/3ebaa88953d7458785bcccb29c6b1bc7 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Neurexins regulate presynaptic GABAB-receptors at central synapses
por: Fujun Luo, et al.
Publicado: (2021) -
Trogocytosis in Unicellular Eukaryotes
por: Kumiko Nakada-Tsukui, et al.
Publicado: (2021) -
Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses
por: Nishant Singh, et al.
Publicado: (2021) -
Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses
por: David Vandael, et al.
Publicado: (2021) -
Author Correction: Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses
por: Nishant Singh, et al.
Publicado: (2021)