Increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.

<h4>Purpose</h4>To investigate the association between retinitis pigmentosa (RP) and acute angle closure during a 15-year follow-up period.<h4>Methods</h4>Using the Taiwan Longitudinal Health Insurance Database 2000, we identified 382 RP patients based on the diagnostic code...

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Autores principales:	Yu-Chieh Ko, Chia-Jen Liu, De-Kuang Hwang, Tzeng-Ji Chen, Catherine J Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ebb2cde81fb481e9b540e44cf785a55
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spelling	oai:doaj.org-article:3ebb2cde81fb481e9b540e44cf785a552021-11-25T06:00:40ZIncreased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.1932-620310.1371/journal.pone.0107660https://doaj.org/article/3ebb2cde81fb481e9b540e44cf785a552014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0107660https://doaj.org/toc/1932-6203<h4>Purpose</h4>To investigate the association between retinitis pigmentosa (RP) and acute angle closure during a 15-year follow-up period.<h4>Methods</h4>Using the Taiwan Longitudinal Health Insurance Database 2000, we identified 382 RP patients based on the diagnostic code of RP (International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) 362.74) made during 1996-2010, excluding subjects under age of 20 years at diagnosis or subjects undergoing lens extraction before the index date. The control group included 3820 randomly selected non-RP subjects matched with the RP patients in age, gender and the index date of diagnosis. The incidence of acute angle closure during the study period was observed based on an ICD-9-CM code of 365.22. Cochran-Mantel-Haenszel test was used to determine the odds ratio (OR) of having acute angle closure in RP patients.<h4>Results</h4>The mean age at the diagnosis of RP was 51.1 years (standard deviation [SD] 16.7). Acute angle closure occurred in 5 RP patients (1.3%) and in 15 controls (0.4%). The mean age with the acute angle closure was 53.3 years (SD 8.0) in RP patients and 64.6 years (SD 8.4) in controls (P = 0.015). After adjusting for age, gender and comorbid disorders, RP patients had 3.64-fold (95% confidence interval [CI], 1.29-10.25, P<0.001) greater odds of having acute angle closure. After stratification for gender and age, the risk of acute angle closure in RP was higher in patients under age of 60 years (adjusted OR 11.84; 95% CI, 2.84-49.48) and male patients (adjusted OR 19.36; 95% CI, 3.43-109.40) (both P = 0.001).<h4>Conclusions</h4>RP patients had increased risk of acute angle closure than controls. Contrary to the fact that angle closure disease is more prevalent in elderly females in general population, acute angle closure attack occurred earlier in life and the risk was higher in males among RP patients.Yu-Chieh KoChia-Jen LiuDe-Kuang HwangTzeng-Ji ChenCatherine J LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e107660 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Chieh Ko Chia-Jen Liu De-Kuang Hwang Tzeng-Ji Chen Catherine J Liu Increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.
description	<h4>Purpose</h4>To investigate the association between retinitis pigmentosa (RP) and acute angle closure during a 15-year follow-up period.<h4>Methods</h4>Using the Taiwan Longitudinal Health Insurance Database 2000, we identified 382 RP patients based on the diagnostic code of RP (International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) 362.74) made during 1996-2010, excluding subjects under age of 20 years at diagnosis or subjects undergoing lens extraction before the index date. The control group included 3820 randomly selected non-RP subjects matched with the RP patients in age, gender and the index date of diagnosis. The incidence of acute angle closure during the study period was observed based on an ICD-9-CM code of 365.22. Cochran-Mantel-Haenszel test was used to determine the odds ratio (OR) of having acute angle closure in RP patients.<h4>Results</h4>The mean age at the diagnosis of RP was 51.1 years (standard deviation [SD] 16.7). Acute angle closure occurred in 5 RP patients (1.3%) and in 15 controls (0.4%). The mean age with the acute angle closure was 53.3 years (SD 8.0) in RP patients and 64.6 years (SD 8.4) in controls (P = 0.015). After adjusting for age, gender and comorbid disorders, RP patients had 3.64-fold (95% confidence interval [CI], 1.29-10.25, P<0.001) greater odds of having acute angle closure. After stratification for gender and age, the risk of acute angle closure in RP was higher in patients under age of 60 years (adjusted OR 11.84; 95% CI, 2.84-49.48) and male patients (adjusted OR 19.36; 95% CI, 3.43-109.40) (both P = 0.001).<h4>Conclusions</h4>RP patients had increased risk of acute angle closure than controls. Contrary to the fact that angle closure disease is more prevalent in elderly females in general population, acute angle closure attack occurred earlier in life and the risk was higher in males among RP patients.
format	article
author	Yu-Chieh Ko Chia-Jen Liu De-Kuang Hwang Tzeng-Ji Chen Catherine J Liu
author_facet	Yu-Chieh Ko Chia-Jen Liu De-Kuang Hwang Tzeng-Ji Chen Catherine J Liu
author_sort	Yu-Chieh Ko
title	Increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.
title_short	Increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.
title_full	Increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.
title_fullStr	Increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.
title_full_unstemmed	Increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.
title_sort	increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3ebb2cde81fb481e9b540e44cf785a55
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Increased risk of acute angle closure in retinitis pigmentosa: a population-based case-control study.

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