The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection

ISG15 is a ubiquitin-like modifier that can be upregulated in response to bacterial infections. Here, the authors use proteomics to identify endogenous ISGylation substrates in the liver of Listeria monocytogenes infected mice and show that ISGylation alters basal and infection-induced autophagy.

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Autores principales:	Yifeng Zhang, Fabien Thery, Nicholas C. Wu, Emma K. Luhmann, Olivier Dussurget, Mariko Foecke, Clara Bredow, Daniel Jiménez-Fernández, Kevin Leandro, Antje Beling, Klaus-Peter Knobeloch, Francis Impens, Pascale Cossart, Lilliana Radoshevich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ec566daad4b41d8b8622180c6d91133
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spelling	oai:doaj.org-article:3ec566daad4b41d8b8622180c6d911332021-12-02T15:35:29ZThe in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection10.1038/s41467-019-13393-x2041-1723https://doaj.org/article/3ec566daad4b41d8b8622180c6d911332019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13393-xhttps://doaj.org/toc/2041-1723ISG15 is a ubiquitin-like modifier that can be upregulated in response to bacterial infections. Here, the authors use proteomics to identify endogenous ISGylation substrates in the liver of Listeria monocytogenes infected mice and show that ISGylation alters basal and infection-induced autophagy.Yifeng ZhangFabien TheryNicholas C. WuEmma K. LuhmannOlivier DussurgetMariko FoeckeClara BredowDaniel Jiménez-FernándezKevin LeandroAntje BelingKlaus-Peter KnobelochFrancis ImpensPascale CossartLilliana RadoshevichNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifeng Zhang Fabien Thery Nicholas C. Wu Emma K. Luhmann Olivier Dussurget Mariko Foecke Clara Bredow Daniel Jiménez-Fernández Kevin Leandro Antje Beling Klaus-Peter Knobeloch Francis Impens Pascale Cossart Lilliana Radoshevich The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
description	ISG15 is a ubiquitin-like modifier that can be upregulated in response to bacterial infections. Here, the authors use proteomics to identify endogenous ISGylation substrates in the liver of Listeria monocytogenes infected mice and show that ISGylation alters basal and infection-induced autophagy.
format	article
author	Yifeng Zhang Fabien Thery Nicholas C. Wu Emma K. Luhmann Olivier Dussurget Mariko Foecke Clara Bredow Daniel Jiménez-Fernández Kevin Leandro Antje Beling Klaus-Peter Knobeloch Francis Impens Pascale Cossart Lilliana Radoshevich
author_facet	Yifeng Zhang Fabien Thery Nicholas C. Wu Emma K. Luhmann Olivier Dussurget Mariko Foecke Clara Bredow Daniel Jiménez-Fernández Kevin Leandro Antje Beling Klaus-Peter Knobeloch Francis Impens Pascale Cossart Lilliana Radoshevich
author_sort	Yifeng Zhang
title	The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
title_short	The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
title_full	The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
title_fullStr	The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
title_full_unstemmed	The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
title_sort	in vivo isgylome links isg15 to metabolic pathways and autophagy upon listeria monocytogenes infection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3ec566daad4b41d8b8622180c6d91133
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The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection

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