Restoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation

ABSTRACT Gram-negative bacteria produce an asymmetric outer membrane (OM) that is particularly impermeant to many antibiotics and characterized by lipopolysaccharide (LPS) exclusively at the cell surface. LPS biogenesis remains an ideal target for therapeutic intervention, as disruption could kill b...

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Autores principales:	Brent W. Simpson, Martin V. Douglass, M. Stephen Trent
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	LapA LapB LpxC PbgA YejM cardiolipin Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3ec61e3555304504af131d74e90b253e
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spelling	oai:doaj.org-article:3ec61e3555304504af131d74e90b253e2021-11-15T15:55:44ZRestoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation10.1128/mBio.02624-202150-7511https://doaj.org/article/3ec61e3555304504af131d74e90b253e2020-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02624-20https://doaj.org/toc/2150-7511ABSTRACT Gram-negative bacteria produce an asymmetric outer membrane (OM) that is particularly impermeant to many antibiotics and characterized by lipopolysaccharide (LPS) exclusively at the cell surface. LPS biogenesis remains an ideal target for therapeutic intervention, as disruption could kill bacteria or increase sensitivity to existing antibiotics. While it has been known that LPS synthesis is regulated by proteolytic control of LpxC, the enzyme that catalyzes the first committed step of LPS synthesis, it remains unknown which signals direct this regulation. New details have been revealed during study of a cryptic essential inner membrane protein, YejM. Multiple functions have been proposed over the years for YejM, including a controversial hypothesis that it transports cardiolipin from the inner membrane to the OM. Strong evidence now indicates that YejM senses LPS in the periplasm and directs proteolytic regulation. Here, we discuss the standing literature of YejM and highlight exciting new insights into cell envelope maintenance.Brent W. SimpsonMartin V. DouglassM. Stephen TrentAmerican Society for MicrobiologyarticleLapALapBLpxCPbgAYejMcardiolipinMicrobiologyQR1-502ENmBio, Vol 11, Iss 6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	LapA LapB LpxC PbgA YejM cardiolipin Microbiology QR1-502
spellingShingle	LapA LapB LpxC PbgA YejM cardiolipin Microbiology QR1-502 Brent W. Simpson Martin V. Douglass M. Stephen Trent Restoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation
description	ABSTRACT Gram-negative bacteria produce an asymmetric outer membrane (OM) that is particularly impermeant to many antibiotics and characterized by lipopolysaccharide (LPS) exclusively at the cell surface. LPS biogenesis remains an ideal target for therapeutic intervention, as disruption could kill bacteria or increase sensitivity to existing antibiotics. While it has been known that LPS synthesis is regulated by proteolytic control of LpxC, the enzyme that catalyzes the first committed step of LPS synthesis, it remains unknown which signals direct this regulation. New details have been revealed during study of a cryptic essential inner membrane protein, YejM. Multiple functions have been proposed over the years for YejM, including a controversial hypothesis that it transports cardiolipin from the inner membrane to the OM. Strong evidence now indicates that YejM senses LPS in the periplasm and directs proteolytic regulation. Here, we discuss the standing literature of YejM and highlight exciting new insights into cell envelope maintenance.
format	article
author	Brent W. Simpson Martin V. Douglass M. Stephen Trent
author_facet	Brent W. Simpson Martin V. Douglass M. Stephen Trent
author_sort	Brent W. Simpson
title	Restoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation
title_short	Restoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation
title_full	Restoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation
title_fullStr	Restoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation
title_full_unstemmed	Restoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation
title_sort	restoring balance to the outer membrane: yejm’s role in lps regulation
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/3ec61e3555304504af131d74e90b253e
work_keys_str_mv	AT brentwsimpson restoringbalancetotheoutermembraneyejmsroleinlpsregulation AT martinvdouglass restoringbalancetotheoutermembraneyejmsroleinlpsregulation AT mstephentrent restoringbalancetotheoutermembraneyejmsroleinlpsregulation
_version_	1718427144767406080

Restoring Balance to the Outer Membrane: YejM’s Role in LPS Regulation

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