Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles

Limited understanding of the interactions between nanoparticle drug carriers and the blood-brain barrier underlies many translational failures in treatments of brain disorders. Here the authors use two-photon microscopy in mice to characterize the receptor-mediated transcytosis of nanoparticles at a...

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Autores principales:	Krzysztof Kucharz, Kasper Kristensen, Kasper Bendix Johnsen, Mette Aagaard Lund, Micael Lønstrup, Torben Moos, Thomas Lars Andresen, Martin Johannes Lauritzen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ecb3577f7e2486e85315477978e25ca
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spelling	oai:doaj.org-article:3ecb3577f7e2486e85315477978e25ca2021-12-02T16:14:58ZPost-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles10.1038/s41467-021-24323-12041-1723https://doaj.org/article/3ecb3577f7e2486e85315477978e25ca2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24323-1https://doaj.org/toc/2041-1723Limited understanding of the interactions between nanoparticle drug carriers and the blood-brain barrier underlies many translational failures in treatments of brain disorders. Here the authors use two-photon microscopy in mice to characterize the receptor-mediated transcytosis of nanoparticles at all steps of delivery from the blood to the brain in vivo.Krzysztof KucharzKasper KristensenKasper Bendix JohnsenMette Aagaard LundMicael LønstrupTorben MoosThomas Lars AndresenMartin Johannes LauritzenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krzysztof Kucharz Kasper Kristensen Kasper Bendix Johnsen Mette Aagaard Lund Micael Lønstrup Torben Moos Thomas Lars Andresen Martin Johannes Lauritzen Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
description	Limited understanding of the interactions between nanoparticle drug carriers and the blood-brain barrier underlies many translational failures in treatments of brain disorders. Here the authors use two-photon microscopy in mice to characterize the receptor-mediated transcytosis of nanoparticles at all steps of delivery from the blood to the brain in vivo.
format	article
author	Krzysztof Kucharz Kasper Kristensen Kasper Bendix Johnsen Mette Aagaard Lund Micael Lønstrup Torben Moos Thomas Lars Andresen Martin Johannes Lauritzen
author_facet	Krzysztof Kucharz Kasper Kristensen Kasper Bendix Johnsen Mette Aagaard Lund Micael Lønstrup Torben Moos Thomas Lars Andresen Martin Johannes Lauritzen
author_sort	Krzysztof Kucharz
title	Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
title_short	Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
title_full	Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
title_fullStr	Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
title_full_unstemmed	Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
title_sort	post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ecb3577f7e2486e85315477978e25ca
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Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles

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