Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues

Anomia is the most frequent and pervasive symptom for people with aphasia (PWA). Phonological component analysis (PCA) is a therapy incorporating phonological cues to treat anomia. Investigations of neural correlates supporting improvements following PCA remain scarce. Resting-state functional conne...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michèle Masson-Trottier, Anna Sontheimer, Edith Durand, Ana Inés Ansaldo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aphasia anomia therapy resting-state fMRI French Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/3ed45c583f524d069f7e5ca32f651b4b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3ed45c583f524d069f7e5ca32f651b4b
record_format	dspace
spelling	oai:doaj.org-article:3ed45c583f524d069f7e5ca32f651b4b2021-11-25T16:57:47ZResting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues10.3390/brainsci111114582076-3425https://doaj.org/article/3ed45c583f524d069f7e5ca32f651b4b2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1458https://doaj.org/toc/2076-3425Anomia is the most frequent and pervasive symptom for people with aphasia (PWA). Phonological component analysis (PCA) is a therapy incorporating phonological cues to treat anomia. Investigations of neural correlates supporting improvements following PCA remain scarce. Resting-state functional connectivity (rsFC) as a marker of therapy-induced neuroplasticity has been reported by our team. The present study explores the efficacy of PCA in French and associated therapy-induced neuroplasticity using whole-brain rsFC analysis. Ten PWA participated in a pre-/post-PCA fMRI study with cognitive linguistic assessments. PCA was delivered in French following the standard procedure. PCA led to significant improvement with trained and untrained items. PCA also led to changes in rsFC between distributed ROIs in the semantic network, visual network, and sub-cortical areas. Changes in rsFC can be interpreted within the frame of the visual and phonological nature of PCA. Behavioral and rsFC data changes associated with PCA in French highlight its efficacy and point to the importance of phonological and orthographic cues to consolidate the word-retrieval strategy, contributing to generalization to untrained words.Michèle Masson-TrottierAnna SontheimerEdith DurandAna Inés AnsaldoMDPI AGarticleaphasiaanomiatherapyresting-state fMRIFrenchNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1458, p 1458 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aphasia anomia therapy resting-state fMRI French Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	aphasia anomia therapy resting-state fMRI French Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Michèle Masson-Trottier Anna Sontheimer Edith Durand Ana Inés Ansaldo Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues
description	Anomia is the most frequent and pervasive symptom for people with aphasia (PWA). Phonological component analysis (PCA) is a therapy incorporating phonological cues to treat anomia. Investigations of neural correlates supporting improvements following PCA remain scarce. Resting-state functional connectivity (rsFC) as a marker of therapy-induced neuroplasticity has been reported by our team. The present study explores the efficacy of PCA in French and associated therapy-induced neuroplasticity using whole-brain rsFC analysis. Ten PWA participated in a pre-/post-PCA fMRI study with cognitive linguistic assessments. PCA was delivered in French following the standard procedure. PCA led to significant improvement with trained and untrained items. PCA also led to changes in rsFC between distributed ROIs in the semantic network, visual network, and sub-cortical areas. Changes in rsFC can be interpreted within the frame of the visual and phonological nature of PCA. Behavioral and rsFC data changes associated with PCA in French highlight its efficacy and point to the importance of phonological and orthographic cues to consolidate the word-retrieval strategy, contributing to generalization to untrained words.
format	article
author	Michèle Masson-Trottier Anna Sontheimer Edith Durand Ana Inés Ansaldo
author_facet	Michèle Masson-Trottier Anna Sontheimer Edith Durand Ana Inés Ansaldo
author_sort	Michèle Masson-Trottier
title	Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues
title_short	Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues
title_full	Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues
title_fullStr	Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues
title_full_unstemmed	Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues
title_sort	resting-state functional connectivity following phonological component analysis: the combined action of phonology and visual orthographic cues
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3ed45c583f524d069f7e5ca32f651b4b
work_keys_str_mv	AT michelemassontrottier restingstatefunctionalconnectivityfollowingphonologicalcomponentanalysisthecombinedactionofphonologyandvisualorthographiccues AT annasontheimer restingstatefunctionalconnectivityfollowingphonologicalcomponentanalysisthecombinedactionofphonologyandvisualorthographiccues AT edithdurand restingstatefunctionalconnectivityfollowingphonologicalcomponentanalysisthecombinedactionofphonologyandvisualorthographiccues AT anainesansaldo restingstatefunctionalconnectivityfollowingphonologicalcomponentanalysisthecombinedactionofphonologyandvisualorthographiccues
_version_	1718412832860536832

Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues

Ejemplares similares