BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.

BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized. We investigated the impact of BCG vaccination on the frequencies of T...

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Autores principales:	Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jayadeepa, Nandhini Selvaraj, Dinesh Asokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ed7f03c4a8c4ae4968d16612cfed3b7
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spelling	oai:doaj.org-article:3ed7f03c4a8c4ae4968d16612cfed3b72021-12-02T20:16:23ZBCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.1932-620310.1371/journal.pone.0258743https://doaj.org/article/3ed7f03c4a8c4ae4968d16612cfed3b72021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258743https://doaj.org/toc/1932-6203BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized. We investigated the impact of BCG vaccination on the frequencies of T cell subsets and common gamma c (γc) cytokines in a group of healthy elderly individuals (age 60-80 years) at one month post vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrate that BCG vaccination induced enhanced frequencies of central (p<0.0001) and effector memory (p<0.0001) CD4+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001), stem cell memory (p = 0.0001) CD4+ T cells and regulatory T cells. In addition, BCG vaccination induced enhanced frequencies of central (p = 0.0008), effector (p<0.0001) and terminal effector memory (p<0.0001) CD8+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001) and stem cell memory (p = 0.0034) CD8+T cells. BCG vaccination also induced enhanced plasma levels of IL-7 (p<0.0001) and IL-15 (p = 0.0020) but diminished levels of IL-2 (p = 0.0033) and IL-21 (p = 0.0020). Thus, BCG vaccination was associated with enhanced memory T cell subsets as well as memory enhancing γc cytokines in elderly individuals, suggesting its ability to induce non-specific adaptive immune responses.Nathella Pavan KumarChandrasekaran PadmapriyadarsiniAnuradha RajamanickamPerumal Kannabiran BhavaniArul NancyBharathi JayadeepaNandhini SelvarajDinesh AsokanRachel Mariam RenjiVijayalakshmi VenkataramaniSrikanth TripathySubash BabuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0258743 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nathella Pavan Kumar Chandrasekaran Padmapriyadarsini Anuradha Rajamanickam Perumal Kannabiran Bhavani Arul Nancy Bharathi Jayadeepa Nandhini Selvaraj Dinesh Asokan Rachel Mariam Renji Vijayalakshmi Venkataramani Srikanth Tripathy Subash Babu BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.
description	BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized. We investigated the impact of BCG vaccination on the frequencies of T cell subsets and common gamma c (γc) cytokines in a group of healthy elderly individuals (age 60-80 years) at one month post vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrate that BCG vaccination induced enhanced frequencies of central (p<0.0001) and effector memory (p<0.0001) CD4+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001), stem cell memory (p = 0.0001) CD4+ T cells and regulatory T cells. In addition, BCG vaccination induced enhanced frequencies of central (p = 0.0008), effector (p<0.0001) and terminal effector memory (p<0.0001) CD8+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001) and stem cell memory (p = 0.0034) CD8+T cells. BCG vaccination also induced enhanced plasma levels of IL-7 (p<0.0001) and IL-15 (p = 0.0020) but diminished levels of IL-2 (p = 0.0033) and IL-21 (p = 0.0020). Thus, BCG vaccination was associated with enhanced memory T cell subsets as well as memory enhancing γc cytokines in elderly individuals, suggesting its ability to induce non-specific adaptive immune responses.
format	article
author	Nathella Pavan Kumar Chandrasekaran Padmapriyadarsini Anuradha Rajamanickam Perumal Kannabiran Bhavani Arul Nancy Bharathi Jayadeepa Nandhini Selvaraj Dinesh Asokan Rachel Mariam Renji Vijayalakshmi Venkataramani Srikanth Tripathy Subash Babu
author_facet	Nathella Pavan Kumar Chandrasekaran Padmapriyadarsini Anuradha Rajamanickam Perumal Kannabiran Bhavani Arul Nancy Bharathi Jayadeepa Nandhini Selvaraj Dinesh Asokan Rachel Mariam Renji Vijayalakshmi Venkataramani Srikanth Tripathy Subash Babu
author_sort	Nathella Pavan Kumar
title	BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.
title_short	BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.
title_full	BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.
title_fullStr	BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.
title_full_unstemmed	BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.
title_sort	bcg vaccination induces enhanced frequencies of memory t cells and altered plasma levels of common γc cytokines in elderly individuals.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3ed7f03c4a8c4ae4968d16612cfed3b7
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BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.

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