Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.

Inclusion of women in research on Alcohol Use Disorder (AUD) has shown that gender differences contribute to unique profiles of cognitive, emotional, and neuropsychological dysfunction. We employed functional magnetic resonance imaging (fMRI) of abstinent individuals with a history of AUD (21 women...

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Autores principales:	Marlene Oscar-Berman, Susan Mosher Ruiz, Ksenija Marinkovic, Mary M Valmas, Gordon J Harris, Kayle S Sawyer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3edb014017a245a69e99330b706b0266
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spelling	oai:doaj.org-article:3edb014017a245a69e99330b706b02662021-12-02T20:10:56ZBrain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.1932-620310.1371/journal.pone.0248831https://doaj.org/article/3edb014017a245a69e99330b706b02662021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0248831https://doaj.org/toc/1932-6203Inclusion of women in research on Alcohol Use Disorder (AUD) has shown that gender differences contribute to unique profiles of cognitive, emotional, and neuropsychological dysfunction. We employed functional magnetic resonance imaging (fMRI) of abstinent individuals with a history of AUD (21 women [AUDw], 21 men [AUDm]) and demographically similar non-AUD control (NC) participants without AUD (21 women [NCw], 21 men [NCm]) to explore how gender and AUD interact to influence brain responses during emotional processing and memory. Participants completed a delayed match-to-sample emotional face memory fMRI task, and brain activation contrasts between a fixation stimulus and pictures of emotional face elicited a similar overall pattern of activation for all four groups. Significant Group by Gender interactions revealed two activation clusters. A cluster in an anterior portion of the middle and superior temporal gyrus, elicited lower activation to the fixation stimulus than to faces for the AUDw as compared to the NCw; that abnormality was more pronounced than the one observed for men. Another cluster in the medial portion of the superior frontal cortex elicited higher activation to the faces by AUDm than NCm, a difference that was more evident than the one observed for women. Together, these findings have added new evidence of AUD-related gender differences in neural responses to facial expressions of emotion.Marlene Oscar-BermanSusan Mosher RuizKsenija MarinkovicMary M ValmasGordon J HarrisKayle S SawyerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0248831 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marlene Oscar-Berman Susan Mosher Ruiz Ksenija Marinkovic Mary M Valmas Gordon J Harris Kayle S Sawyer Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.
description	Inclusion of women in research on Alcohol Use Disorder (AUD) has shown that gender differences contribute to unique profiles of cognitive, emotional, and neuropsychological dysfunction. We employed functional magnetic resonance imaging (fMRI) of abstinent individuals with a history of AUD (21 women [AUDw], 21 men [AUDm]) and demographically similar non-AUD control (NC) participants without AUD (21 women [NCw], 21 men [NCm]) to explore how gender and AUD interact to influence brain responses during emotional processing and memory. Participants completed a delayed match-to-sample emotional face memory fMRI task, and brain activation contrasts between a fixation stimulus and pictures of emotional face elicited a similar overall pattern of activation for all four groups. Significant Group by Gender interactions revealed two activation clusters. A cluster in an anterior portion of the middle and superior temporal gyrus, elicited lower activation to the fixation stimulus than to faces for the AUDw as compared to the NCw; that abnormality was more pronounced than the one observed for men. Another cluster in the medial portion of the superior frontal cortex elicited higher activation to the faces by AUDm than NCm, a difference that was more evident than the one observed for women. Together, these findings have added new evidence of AUD-related gender differences in neural responses to facial expressions of emotion.
format	article
author	Marlene Oscar-Berman Susan Mosher Ruiz Ksenija Marinkovic Mary M Valmas Gordon J Harris Kayle S Sawyer
author_facet	Marlene Oscar-Berman Susan Mosher Ruiz Ksenija Marinkovic Mary M Valmas Gordon J Harris Kayle S Sawyer
author_sort	Marlene Oscar-Berman
title	Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.
title_short	Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.
title_full	Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.
title_fullStr	Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.
title_full_unstemmed	Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.
title_sort	brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3edb014017a245a69e99330b706b0266
work_keys_str_mv	AT marleneoscarberman brainresponsivitytoemotionalfacesdiffersinmenandwomenwithandwithoutahistoryofalcoholusedisorder AT susanmosherruiz brainresponsivitytoemotionalfacesdiffersinmenandwomenwithandwithoutahistoryofalcoholusedisorder AT ksenijamarinkovic brainresponsivitytoemotionalfacesdiffersinmenandwomenwithandwithoutahistoryofalcoholusedisorder AT marymvalmas brainresponsivitytoemotionalfacesdiffersinmenandwomenwithandwithoutahistoryofalcoholusedisorder AT gordonjharris brainresponsivitytoemotionalfacesdiffersinmenandwomenwithandwithoutahistoryofalcoholusedisorder AT kaylessawyer brainresponsivitytoemotionalfacesdiffersinmenandwomenwithandwithoutahistoryofalcoholusedisorder
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Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.

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