Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression

GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.

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Autores principales:	Ying Jin, Genevieve H. L. Roberts, Tracey M. Ferrara, Songtao Ben, Nanja van Geel, Albert Wolkerstorfer, Khaled Ezzedine, Janet Siebert, Charles P. Neff, Brent E. Palmer, Stephanie A. Santorico, Richard A. Spritz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3edf3eefa11e40429926cb0f0aa5c365
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spelling	oai:doaj.org-article:3edf3eefa11e40429926cb0f0aa5c3652021-12-02T15:35:39ZEarly-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression10.1038/s41467-019-08337-42041-1723https://doaj.org/article/3edf3eefa11e40429926cb0f0aa5c3652019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08337-4https://doaj.org/toc/2041-1723GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.Ying JinGenevieve H. L. RobertsTracey M. FerraraSongtao BenNanja van GeelAlbert WolkerstorferKhaled EzzedineJanet SiebertCharles P. NeffBrent E. PalmerStephanie A. SantoricoRichard A. SpritzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Jin Genevieve H. L. Roberts Tracey M. Ferrara Songtao Ben Nanja van Geel Albert Wolkerstorfer Khaled Ezzedine Janet Siebert Charles P. Neff Brent E. Palmer Stephanie A. Santorico Richard A. Spritz Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression
description	GWAS have led to the identification of 49 genetic loci associated with vitiligo. Here, the authors observe a bimodal distribution of age-of-onset and find a novel genetic locus specifically associated with early-onset vitiligo, located in a regulatory element in the MHC class II region.
format	article
author	Ying Jin Genevieve H. L. Roberts Tracey M. Ferrara Songtao Ben Nanja van Geel Albert Wolkerstorfer Khaled Ezzedine Janet Siebert Charles P. Neff Brent E. Palmer Stephanie A. Santorico Richard A. Spritz
author_facet	Ying Jin Genevieve H. L. Roberts Tracey M. Ferrara Songtao Ben Nanja van Geel Albert Wolkerstorfer Khaled Ezzedine Janet Siebert Charles P. Neff Brent E. Palmer Stephanie A. Santorico Richard A. Spritz
author_sort	Ying Jin
title	Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression
title_short	Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression
title_full	Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression
title_fullStr	Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression
title_full_unstemmed	Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression
title_sort	early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class ii hla expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3edf3eefa11e40429926cb0f0aa5c365
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Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression

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