Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and recovery.

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Autores principales:	Stefan A. Berghoff, Nina Gerndt, Jan Winchenbach, Sina K. Stumpf, Leon Hosang, Francesca Odoardi, Torben Ruhwedel, Carolin Böhler, Benoit Barrette, Ruth Stassart, David Liebetanz, Payam Dibaj, Wiebke Möbius, Julia M. Edgar, Gesine Saher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ee45ebdd5304a2ead8ae8d4b159b5bf
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spelling	oai:doaj.org-article:3ee45ebdd5304a2ead8ae8d4b159b5bf2021-12-02T15:39:03ZDietary cholesterol promotes repair of demyelinated lesions in the adult brain10.1038/ncomms142412041-1723https://doaj.org/article/3ee45ebdd5304a2ead8ae8d4b159b5bf2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14241https://doaj.org/toc/2041-1723Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and recovery.Stefan A. BerghoffNina GerndtJan WinchenbachSina K. StumpfLeon HosangFrancesca OdoardiTorben RuhwedelCarolin BöhlerBenoit BarretteRuth StassartDavid LiebetanzPayam DibajWiebke MöbiusJulia M. EdgarGesine SaherNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefan A. Berghoff Nina Gerndt Jan Winchenbach Sina K. Stumpf Leon Hosang Francesca Odoardi Torben Ruhwedel Carolin Böhler Benoit Barrette Ruth Stassart David Liebetanz Payam Dibaj Wiebke Möbius Julia M. Edgar Gesine Saher Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
description	Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and recovery.
format	article
author	Stefan A. Berghoff Nina Gerndt Jan Winchenbach Sina K. Stumpf Leon Hosang Francesca Odoardi Torben Ruhwedel Carolin Böhler Benoit Barrette Ruth Stassart David Liebetanz Payam Dibaj Wiebke Möbius Julia M. Edgar Gesine Saher
author_facet	Stefan A. Berghoff Nina Gerndt Jan Winchenbach Sina K. Stumpf Leon Hosang Francesca Odoardi Torben Ruhwedel Carolin Böhler Benoit Barrette Ruth Stassart David Liebetanz Payam Dibaj Wiebke Möbius Julia M. Edgar Gesine Saher
author_sort	Stefan A. Berghoff
title	Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
title_short	Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
title_full	Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
title_fullStr	Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
title_full_unstemmed	Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
title_sort	dietary cholesterol promotes repair of demyelinated lesions in the adult brain
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3ee45ebdd5304a2ead8ae8d4b159b5bf
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Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

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