Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation

Abstract The NR3C1 glucocorticoid receptor (GR) gene is a component of the stress response system, which can be regulated by epigenetic mechanisms. NR3C1 methylation has been associated with trauma and mental issues, including depression, post-traumatic stress, anxiety, and personality disorders. Pr...

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Autores principales:	Júlia de Assis Pinheiro, Flávia Vitorino Freitas, Aline Ribeiro Borçoi, Suzanny Oliveira Mendes, Catarine Lima Conti, Juliana Krüger Arpini, Tamires dos Santos Vieira, Rafael Assis de Souza, Dirceu Pereira dos Santos, Wagner Miranda Barbosa, Anderson Barros Archanjo, Mayara Mota de Oliveira, Joaquim Gasparini dos Santos, Bruna Pereira Sorroche, José Claudio Casali-da-Rocha, Leonardo Oliveira Trivilin, Elizeu Batista Borloti, Iuri Drumond Louro, Lidia Maria Rebolho Batista Arantes, Adriana Madeira Alvares-da-Silva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ee46a3fb1d94e37bf89418044be54f7
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spelling	oai:doaj.org-article:3ee46a3fb1d94e37bf89418044be54f72021-12-02T17:04:05ZAlcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation10.1038/s41598-021-86189-z2045-2322https://doaj.org/article/3ee46a3fb1d94e37bf89418044be54f72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86189-zhttps://doaj.org/toc/2045-2322Abstract The NR3C1 glucocorticoid receptor (GR) gene is a component of the stress response system, which can be regulated by epigenetic mechanisms. NR3C1 methylation has been associated with trauma and mental issues, including depression, post-traumatic stress, anxiety, and personality disorders. Previous studies have reported that stressful events are involved in NR3C1 gene methylation, suggesting that its regulation under environmental effects is complex. The present study aimed to analyze associations involving stressors such as socioeconomic status, health conditions, and lifestyle in relation to NR3C1 methylation in adults. This study included 386 individual users of the Brazilian Public Unified Health System (SUS), and evaluated socioeconomic and health conditions, body mass index, cortisol levels, and lifestyle. Data were correlated with NR3C1 methylation, determined using DNA pyrosequencing. The results showed that alcohol consumption, overweight, and high cortisol levels were related to NR3C1 demethylation, while depression was related to its methylation. Habits, lifestyle, and health status may influence NR3C1 gene regulation via methylation, revealing the complexity of environmental impacts on NR3C1 methylation.Júlia de Assis PinheiroFlávia Vitorino FreitasAline Ribeiro BorçoiSuzanny Oliveira MendesCatarine Lima ContiJuliana Krüger ArpiniTamires dos Santos VieiraRafael Assis de SouzaDirceu Pereira dos SantosWagner Miranda BarbosaAnderson Barros ArchanjoMayara Mota de OliveiraJoaquim Gasparini dos SantosBruna Pereira SorrocheJosé Claudio Casali-da-RochaLeonardo Oliveira TrivilinElizeu Batista BorlotiIuri Drumond LouroLidia Maria Rebolho Batista ArantesAdriana Madeira Alvares-da-SilvaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Júlia de Assis Pinheiro Flávia Vitorino Freitas Aline Ribeiro Borçoi Suzanny Oliveira Mendes Catarine Lima Conti Juliana Krüger Arpini Tamires dos Santos Vieira Rafael Assis de Souza Dirceu Pereira dos Santos Wagner Miranda Barbosa Anderson Barros Archanjo Mayara Mota de Oliveira Joaquim Gasparini dos Santos Bruna Pereira Sorroche José Claudio Casali-da-Rocha Leonardo Oliveira Trivilin Elizeu Batista Borloti Iuri Drumond Louro Lidia Maria Rebolho Batista Arantes Adriana Madeira Alvares-da-Silva Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation
description	Abstract The NR3C1 glucocorticoid receptor (GR) gene is a component of the stress response system, which can be regulated by epigenetic mechanisms. NR3C1 methylation has been associated with trauma and mental issues, including depression, post-traumatic stress, anxiety, and personality disorders. Previous studies have reported that stressful events are involved in NR3C1 gene methylation, suggesting that its regulation under environmental effects is complex. The present study aimed to analyze associations involving stressors such as socioeconomic status, health conditions, and lifestyle in relation to NR3C1 methylation in adults. This study included 386 individual users of the Brazilian Public Unified Health System (SUS), and evaluated socioeconomic and health conditions, body mass index, cortisol levels, and lifestyle. Data were correlated with NR3C1 methylation, determined using DNA pyrosequencing. The results showed that alcohol consumption, overweight, and high cortisol levels were related to NR3C1 demethylation, while depression was related to its methylation. Habits, lifestyle, and health status may influence NR3C1 gene regulation via methylation, revealing the complexity of environmental impacts on NR3C1 methylation.
format	article
author	Júlia de Assis Pinheiro Flávia Vitorino Freitas Aline Ribeiro Borçoi Suzanny Oliveira Mendes Catarine Lima Conti Juliana Krüger Arpini Tamires dos Santos Vieira Rafael Assis de Souza Dirceu Pereira dos Santos Wagner Miranda Barbosa Anderson Barros Archanjo Mayara Mota de Oliveira Joaquim Gasparini dos Santos Bruna Pereira Sorroche José Claudio Casali-da-Rocha Leonardo Oliveira Trivilin Elizeu Batista Borloti Iuri Drumond Louro Lidia Maria Rebolho Batista Arantes Adriana Madeira Alvares-da-Silva
author_facet	Júlia de Assis Pinheiro Flávia Vitorino Freitas Aline Ribeiro Borçoi Suzanny Oliveira Mendes Catarine Lima Conti Juliana Krüger Arpini Tamires dos Santos Vieira Rafael Assis de Souza Dirceu Pereira dos Santos Wagner Miranda Barbosa Anderson Barros Archanjo Mayara Mota de Oliveira Joaquim Gasparini dos Santos Bruna Pereira Sorroche José Claudio Casali-da-Rocha Leonardo Oliveira Trivilin Elizeu Batista Borloti Iuri Drumond Louro Lidia Maria Rebolho Batista Arantes Adriana Madeira Alvares-da-Silva
author_sort	Júlia de Assis Pinheiro
title	Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation
title_short	Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation
title_full	Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation
title_fullStr	Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation
title_full_unstemmed	Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation
title_sort	alcohol consumption, depression, overweight and cortisol levels as determining factors for nr3c1 gene methylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ee46a3fb1d94e37bf89418044be54f7
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Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation

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