Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection

The aim of the study was to examine specifics of changes in the level of stomach- and pancreas-released blood hydrolases in chronic viral hepatitis B and analyze the mechanisms underlying such changes. We assessed serum markers of HBV infection, liver enzymes tests as well as gastric and pancreatic...

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Autores principales:	M. A. Zhuraeva, V. A. Aleinik, N. D. Ashuralieva, D. S. Halikova, J. B. Ravzatov, B. K. Abdulazizhozhyv
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2021
Materias:	chronic hepatitis b serum gastric hydrolases pancreatic serum hydrolases pancreatitis atrophic gastritis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/3ee903a6817246a1929282d508d419e3
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spelling	oai:doaj.org-article:3ee903a6817246a1929282d508d419e32021-11-22T07:09:56ZParameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection2220-76192313-739810.15789/2220-7619-POB-1393https://doaj.org/article/3ee903a6817246a1929282d508d419e32021-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1393https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The aim of the study was to examine specifics of changes in the level of stomach- and pancreas-released blood hydrolases in chronic viral hepatitis B and analyze the mechanisms underlying such changes. We assessed serum markers of HBV infection, liver enzymes tests as well as gastric and pancreatic hydrolase level. The patients examined were divided into three groups: control (healthy) and two study groups — HBV post-infection and chronic HBV infection. Patients with HBV post-infection had no significant deviations from normal range for blood level of gastric and pancreatic hydrolases. Patients with chronic HBV infection were found to contain increased blood level of amylase and lipase, which may evidence about increasing pancreatic functional activity and development of covert pancreatitis. At the same time, decline in the concentration of serum pepsinogen-1 below 40 μg/l could indicate about prominently decreased secretion of hydrochloric acid and development of atrophic gastritis, and it was found that the major factor contributing to development of such disorders was the short-chain peptide CCK-8, which utilization declines in patients with chronic HBV infection. CCK-8 can play a pivotal role in inhibiting stimulation of gastric acid secretion and controls gastric acid, plasma gastrin and somatostatin secretion. Cholecystokinin has been found to inhibit acid secretion by activating CCK type A receptors as well as via somatostatin-involving mechanism. The secretion of gastric somatostatin-14 increased by fivefold due to CCK-8 alone, but was blocked by the CCK-A receptor blocker loxiglumide. These data show that CCK-8 directly inhibits acid reactions by stimulating the release of gastric somatostatin indirectly through the CCK-A receptor. Thus, it can be assumed that normally CCK-8 is mainly utilized by the liver, which is altered during chronic hepatitis B resulting in elevated blood CCK-8 concentration. As a consequence, it enhances pancreatic secretion resulting in developing pancreatitis that is paralleled with inhibited gastric secretion and emerged atrophic gastritis.M. A. ZhuraevaV. A. AleinikN. D. AshuralievaD. S. HalikovaJ. B. RavzatovB. K. AbdulazizhozhyvSankt-Peterburg : NIIÈM imeni Pasteraarticlechronic hepatitis bserum gastric hydrolasespancreatic serum hydrolasespancreatitisatrophic gastritisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 11, Iss 5, Pp 973-978 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic hepatitis b serum gastric hydrolases pancreatic serum hydrolases pancreatitis atrophic gastritis Infectious and parasitic diseases RC109-216
spellingShingle	chronic hepatitis b serum gastric hydrolases pancreatic serum hydrolases pancreatitis atrophic gastritis Infectious and parasitic diseases RC109-216 M. A. Zhuraeva V. A. Aleinik N. D. Ashuralieva D. S. Halikova J. B. Ravzatov B. K. Abdulazizhozhyv Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection
description	The aim of the study was to examine specifics of changes in the level of stomach- and pancreas-released blood hydrolases in chronic viral hepatitis B and analyze the mechanisms underlying such changes. We assessed serum markers of HBV infection, liver enzymes tests as well as gastric and pancreatic hydrolase level. The patients examined were divided into three groups: control (healthy) and two study groups — HBV post-infection and chronic HBV infection. Patients with HBV post-infection had no significant deviations from normal range for blood level of gastric and pancreatic hydrolases. Patients with chronic HBV infection were found to contain increased blood level of amylase and lipase, which may evidence about increasing pancreatic functional activity and development of covert pancreatitis. At the same time, decline in the concentration of serum pepsinogen-1 below 40 μg/l could indicate about prominently decreased secretion of hydrochloric acid and development of atrophic gastritis, and it was found that the major factor contributing to development of such disorders was the short-chain peptide CCK-8, which utilization declines in patients with chronic HBV infection. CCK-8 can play a pivotal role in inhibiting stimulation of gastric acid secretion and controls gastric acid, plasma gastrin and somatostatin secretion. Cholecystokinin has been found to inhibit acid secretion by activating CCK type A receptors as well as via somatostatin-involving mechanism. The secretion of gastric somatostatin-14 increased by fivefold due to CCK-8 alone, but was blocked by the CCK-A receptor blocker loxiglumide. These data show that CCK-8 directly inhibits acid reactions by stimulating the release of gastric somatostatin indirectly through the CCK-A receptor. Thus, it can be assumed that normally CCK-8 is mainly utilized by the liver, which is altered during chronic hepatitis B resulting in elevated blood CCK-8 concentration. As a consequence, it enhances pancreatic secretion resulting in developing pancreatitis that is paralleled with inhibited gastric secretion and emerged atrophic gastritis.
format	article
author	M. A. Zhuraeva V. A. Aleinik N. D. Ashuralieva D. S. Halikova J. B. Ravzatov B. K. Abdulazizhozhyv
author_facet	M. A. Zhuraeva V. A. Aleinik N. D. Ashuralieva D. S. Halikova J. B. Ravzatov B. K. Abdulazizhozhyv
author_sort	M. A. Zhuraeva
title	Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection
title_short	Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection
title_full	Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection
title_fullStr	Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection
title_full_unstemmed	Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection
title_sort	parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis b virus infection
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2021
url	https://doaj.org/article/3ee903a6817246a1929282d508d419e3
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Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection

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