Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments

Geis et al. investigate the potential application of hemibodies, a pair of complementary antibody fragments that redirect T cells against cancer-defining antigen combinations, such as CD38 and SLAMF7, to target multiple myeloma. Their study provides evidence that hemibodies can be developed for effe...

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Auteurs principaux:	Maria Geis, Boris Nowotny, Marc-Dominic Bohn, Dina Kouhestani, Hermann Einsele, Thomas Bumm, Gernot Stuhler
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/3ee919498c4342e29413bd80927b94df
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spelling	oai:doaj.org-article:3ee919498c4342e29413bd80927b94df2021-12-02T11:56:22ZCombinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments10.1038/s42003-020-01558-02399-3642https://doaj.org/article/3ee919498c4342e29413bd80927b94df2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01558-0https://doaj.org/toc/2399-3642Geis et al. investigate the potential application of hemibodies, a pair of complementary antibody fragments that redirect T cells against cancer-defining antigen combinations, such as CD38 and SLAMF7, to target multiple myeloma. Their study provides evidence that hemibodies can be developed for effective immunotherapy against multiple myeloma.Maria GeisBoris NowotnyMarc-Dominic BohnDina KouhestaniHermann EinseleThomas BummGernot StuhlerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maria Geis Boris Nowotny Marc-Dominic Bohn Dina Kouhestani Hermann Einsele Thomas Bumm Gernot Stuhler Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments
description	Geis et al. investigate the potential application of hemibodies, a pair of complementary antibody fragments that redirect T cells against cancer-defining antigen combinations, such as CD38 and SLAMF7, to target multiple myeloma. Their study provides evidence that hemibodies can be developed for effective immunotherapy against multiple myeloma.
format	article
author	Maria Geis Boris Nowotny Marc-Dominic Bohn Dina Kouhestani Hermann Einsele Thomas Bumm Gernot Stuhler
author_facet	Maria Geis Boris Nowotny Marc-Dominic Bohn Dina Kouhestani Hermann Einsele Thomas Bumm Gernot Stuhler
author_sort	Maria Geis
title	Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments
title_short	Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments
title_full	Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments
title_fullStr	Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments
title_full_unstemmed	Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments
title_sort	combinatorial targeting of multiple myeloma by complementing t cell engaging antibody fragments
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ee919498c4342e29413bd80927b94df
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Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments

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