Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome

Abstract Knowledge of the Plasmodium falciparum antigens that comprise the human liver stage immunoproteome is important for pre-erythrocytic vaccine development, but, compared with the erythrocytic stage immunoproteome, more challenging to classify. Previous studies of P. falciparum antibody respon...

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Autores principales:	Andrea A. Berry, Joshua M. Obiero, Mark A. Travassos, Amed Ouattara, Drissa Coulibaly, Matthew Adams, Rafael Ramiro de Assis, Aarti Jain, Omid Taghavian, Andrew Sy, Rie Nakajima, Algis Jasinskas, Matthew B. Laurens, Shannon Takala-Harrison, Bourema Kouriba, Abdoulaye K. Kone, Ogobara K. Doumbo, B. Kim Lee Sim, Stephen L. Hoffman, Christopher V. Plowe, Mahamadou A. Thera, Philip L. Felgner, Kirsten E. Lyke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3eee032db8fc4a719cd82982458cdda3
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spelling	oai:doaj.org-article:3eee032db8fc4a719cd82982458cdda32021-12-02T17:25:42ZImmunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome10.1038/s41541-021-00363-y2059-0105https://doaj.org/article/3eee032db8fc4a719cd82982458cdda32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00363-yhttps://doaj.org/toc/2059-0105Abstract Knowledge of the Plasmodium falciparum antigens that comprise the human liver stage immunoproteome is important for pre-erythrocytic vaccine development, but, compared with the erythrocytic stage immunoproteome, more challenging to classify. Previous studies of P. falciparum antibody responses report IgG and rarely IgA responses. We assessed IgG and IgA antibody responses in adult sera collected during two controlled human malaria infection (CHMI) studies in malaria-naïve volunteers and in 1- to 6-year-old malaria-exposed Malian children on a 251 P. falciparum antigen protein microarray. IgG profiles in the two CHMI groups were equivalent and differed from Malian children. IgA profiles were robust in the CHMI groups and a subset of Malian children. We describe immunoproteome differences in naïve vs. exposed individuals and report pre-erythrocytic proteins recognized by the immune system. IgA responses detected in this study expand the list of pre-erythrocytic antigens for further characterization as potential vaccine candidates.Andrea A. BerryJoshua M. ObieroMark A. TravassosAmed OuattaraDrissa CoulibalyMatthew AdamsRafael Ramiro de AssisAarti JainOmid TaghavianAndrew SyRie NakajimaAlgis JasinskasMatthew B. LaurensShannon Takala-HarrisonBourema KouribaAbdoulaye K. KoneOgobara K. DoumboB. Kim Lee SimStephen L. HoffmanChristopher V. PloweMahamadou A. TheraPhilip L. FelgnerKirsten E. LykeNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Andrea A. Berry Joshua M. Obiero Mark A. Travassos Amed Ouattara Drissa Coulibaly Matthew Adams Rafael Ramiro de Assis Aarti Jain Omid Taghavian Andrew Sy Rie Nakajima Algis Jasinskas Matthew B. Laurens Shannon Takala-Harrison Bourema Kouriba Abdoulaye K. Kone Ogobara K. Doumbo B. Kim Lee Sim Stephen L. Hoffman Christopher V. Plowe Mahamadou A. Thera Philip L. Felgner Kirsten E. Lyke Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome
description	Abstract Knowledge of the Plasmodium falciparum antigens that comprise the human liver stage immunoproteome is important for pre-erythrocytic vaccine development, but, compared with the erythrocytic stage immunoproteome, more challenging to classify. Previous studies of P. falciparum antibody responses report IgG and rarely IgA responses. We assessed IgG and IgA antibody responses in adult sera collected during two controlled human malaria infection (CHMI) studies in malaria-naïve volunteers and in 1- to 6-year-old malaria-exposed Malian children on a 251 P. falciparum antigen protein microarray. IgG profiles in the two CHMI groups were equivalent and differed from Malian children. IgA profiles were robust in the CHMI groups and a subset of Malian children. We describe immunoproteome differences in naïve vs. exposed individuals and report pre-erythrocytic proteins recognized by the immune system. IgA responses detected in this study expand the list of pre-erythrocytic antigens for further characterization as potential vaccine candidates.
format	article
author	Andrea A. Berry Joshua M. Obiero Mark A. Travassos Amed Ouattara Drissa Coulibaly Matthew Adams Rafael Ramiro de Assis Aarti Jain Omid Taghavian Andrew Sy Rie Nakajima Algis Jasinskas Matthew B. Laurens Shannon Takala-Harrison Bourema Kouriba Abdoulaye K. Kone Ogobara K. Doumbo B. Kim Lee Sim Stephen L. Hoffman Christopher V. Plowe Mahamadou A. Thera Philip L. Felgner Kirsten E. Lyke
author_facet	Andrea A. Berry Joshua M. Obiero Mark A. Travassos Amed Ouattara Drissa Coulibaly Matthew Adams Rafael Ramiro de Assis Aarti Jain Omid Taghavian Andrew Sy Rie Nakajima Algis Jasinskas Matthew B. Laurens Shannon Takala-Harrison Bourema Kouriba Abdoulaye K. Kone Ogobara K. Doumbo B. Kim Lee Sim Stephen L. Hoffman Christopher V. Plowe Mahamadou A. Thera Philip L. Felgner Kirsten E. Lyke
author_sort	Andrea A. Berry
title	Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome
title_short	Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome
title_full	Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome
title_fullStr	Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome
title_full_unstemmed	Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome
title_sort	immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared iga pre-erythrocytic immunoproteome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3eee032db8fc4a719cd82982458cdda3
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Immunoprofiles associated with controlled human malaria infection and naturally acquired immunity identify a shared IgA pre-erythrocytic immunoproteome

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