Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature

Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature

Abstract Primary Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary and lacrimal glands. The etiology of SS is complex with environmental triggers and genetic factors involved. By conducting an integrated multi-omics stu...

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Autores principales: María Teruel, Guillermo Barturen, Manuel Martínez-Bueno, Olivia Castellini-Pérez, Miguel Barroso-Gil, Elena Povedano, Martin Kerick, Francesc Català-Moll, Zuzanna Makowska, Anne Buttgereit, PRECISESADS Clinical Consortium, PRECISESADS Flow Cytometry Study Group, Jacques-Olivier Pers, Concepción Marañón, Esteban Ballestar, Javier Martin, Elena Carnero-Montoro, Marta E. Alarcón-Riquelme
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3eee442ab7cc476caac7987d806bfc0e
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