Renal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals

Abstract Associations between hepatitis C virus (HCV) and chronic kidney disease (CKD) have been reported; however, differences of renal progression between general and CKD population remain to be elucidated in prospective studies. A total of 1179 participants, who have tested for anti-HCV antibody,...

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Autores principales:	Cheng-Kai Hsu, Tai-Shuan Lai, Yih-Ting Chen, Yi-Ju Tseng, Chin-Chan Lee, Chun-Yu Chen, Heng-Jung Hsu, Heng-Chih Pan, Li-Wei Chen, Cheng-Hung Chien, Chih-Lang Lin, Rong-Nan Chien, I-Wen Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3eeefb7a8b444f56aa2a6a2d4356829e
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spelling	oai:doaj.org-article:3eeefb7a8b444f56aa2a6a2d4356829e2021-12-02T15:09:23ZRenal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals10.1038/s41598-021-96782-x2045-2322https://doaj.org/article/3eeefb7a8b444f56aa2a6a2d4356829e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96782-xhttps://doaj.org/toc/2045-2322Abstract Associations between hepatitis C virus (HCV) and chronic kidney disease (CKD) have been reported; however, differences of renal progression between general and CKD population remain to be elucidated in prospective studies. A total of 1179 participants, who have tested for anti-HCV antibody, were enrolled and prospectively followed for 3 years. The risks associated with HCV infection, in terms of incidence of CKD, annual estimated glomerular filtration rate (eGFR) changes and 50% decline of eGFR at 3-year from baseline, were compared between normal renal function subjects and CKD patients. Overall, 111 of 233 (47.6%) CKD patients and 167 of 946 (17.7%) non-CKD subjects had HCV infection. The crude incidence rates of CKD were 226.9 per 1000 person-years and 14.8 per 1000 person-years in in HCV and non-HCV infected patients, respectively. The adjusted hazard ratio of HCV infection for incident CKD was 7.9 (95% CI 5–12.7). The HCV-infected normal renal function subjects were independently associated with increased risks of eGFR decline in the 1-year, 2-year and 3-year, respectively. The risk associations remained significant in 50% decline of eGFR at 3 years models and in different subgroup analyses. The increases of risks of eGFR decline were also notorious among overall HCV-infected CKD patients. However, the risk associations were less prominent in subgroup analyses (elderly, women and diabetic patients). The findings highlighted the importance of viral diagnosis with not only prognostic but also public health implications for preserving kidney function.Cheng-Kai HsuTai-Shuan LaiYih-Ting ChenYi-Ju TsengChin-Chan LeeChun-Yu ChenHeng-Jung HsuHeng-Chih PanLi-Wei ChenCheng-Hung ChienChih-Lang LinRong-Nan ChienI-Wen WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheng-Kai Hsu Tai-Shuan Lai Yih-Ting Chen Yi-Ju Tseng Chin-Chan Lee Chun-Yu Chen Heng-Jung Hsu Heng-Chih Pan Li-Wei Chen Cheng-Hung Chien Chih-Lang Lin Rong-Nan Chien I-Wen Wu Renal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals
description	Abstract Associations between hepatitis C virus (HCV) and chronic kidney disease (CKD) have been reported; however, differences of renal progression between general and CKD population remain to be elucidated in prospective studies. A total of 1179 participants, who have tested for anti-HCV antibody, were enrolled and prospectively followed for 3 years. The risks associated with HCV infection, in terms of incidence of CKD, annual estimated glomerular filtration rate (eGFR) changes and 50% decline of eGFR at 3-year from baseline, were compared between normal renal function subjects and CKD patients. Overall, 111 of 233 (47.6%) CKD patients and 167 of 946 (17.7%) non-CKD subjects had HCV infection. The crude incidence rates of CKD were 226.9 per 1000 person-years and 14.8 per 1000 person-years in in HCV and non-HCV infected patients, respectively. The adjusted hazard ratio of HCV infection for incident CKD was 7.9 (95% CI 5–12.7). The HCV-infected normal renal function subjects were independently associated with increased risks of eGFR decline in the 1-year, 2-year and 3-year, respectively. The risk associations remained significant in 50% decline of eGFR at 3 years models and in different subgroup analyses. The increases of risks of eGFR decline were also notorious among overall HCV-infected CKD patients. However, the risk associations were less prominent in subgroup analyses (elderly, women and diabetic patients). The findings highlighted the importance of viral diagnosis with not only prognostic but also public health implications for preserving kidney function.
format	article
author	Cheng-Kai Hsu Tai-Shuan Lai Yih-Ting Chen Yi-Ju Tseng Chin-Chan Lee Chun-Yu Chen Heng-Jung Hsu Heng-Chih Pan Li-Wei Chen Cheng-Hung Chien Chih-Lang Lin Rong-Nan Chien I-Wen Wu
author_facet	Cheng-Kai Hsu Tai-Shuan Lai Yih-Ting Chen Yi-Ju Tseng Chin-Chan Lee Chun-Yu Chen Heng-Jung Hsu Heng-Chih Pan Li-Wei Chen Cheng-Hung Chien Chih-Lang Lin Rong-Nan Chien I-Wen Wu
author_sort	Cheng-Kai Hsu
title	Renal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals
title_short	Renal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals
title_full	Renal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals
title_fullStr	Renal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals
title_full_unstemmed	Renal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals
title_sort	renal function trajectories in hepatitis c infection: differences between renal healthy and chronic kidney disease individuals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3eeefb7a8b444f56aa2a6a2d4356829e
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Renal function trajectories in hepatitis C infection: differences between renal healthy and chronic kidney disease individuals

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